Gelatin-based emulsion gels for diffusion-controlled release applications

Goutam Thakur, Muhammad Ali Naqvi, Dérick Rousseau, Kunal Pal, Analava Mitra, Amit Basak

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Emulsion gels are now emerging as a new class of biomaterials for controlled-release applications. Novel food-grade emulsion gels consisting of indomethacin-loaded vegetable oil droplets dispersed within genipin-cross-linked gelatin-based hydrogels were characterized for their physical and drug-release properties. Varying the weight ratio of the aqueous and oil phases between 5:1 and 5:5 was used to modulate construct swelling and drug release. The dispersed oil droplets generally became larger, more polydispersed and aggregated with an increase in oil fraction. Cross-linking with genipin increased the puncture strength of the gels vs. their uncross-linked counterparts and was necessary to prevent breakdown. Swelling of the emulsion gels demonstrated Fickian behaviour at all gelatin: oil ratios. Indomethacin release followed Fickian diffusion at higher oil fractions only, demonstrating coupled Fickian and super-Case-II transport at lower oil ratios (5:1, 5:2 and 5:3). Overall, the introduction of a dispersed oil phase within a hydrogel was exploited for the release of hydrophobic bioactive compounds, with tailoring of composition used to significantly alter release kinetics.

Original languageEnglish
Pages (from-to)645-661
Number of pages17
JournalJournal of Biomaterials Science, Polymer Edition
Volume23
Issue number5
DOIs
Publication statusPublished - 22-03-2012

Fingerprint

Gelatin
Emulsions
Oils
Gels
Hydrogels
Indomethacin
Swelling
Plant Oils
Vegetable oils
Hydrogel
Biocompatible Materials
Punctures
Biomaterials
Pharmaceutical Preparations
Weights and Measures
Food
Kinetics
Chemical analysis

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

Cite this

Thakur, Goutam ; Naqvi, Muhammad Ali ; Rousseau, Dérick ; Pal, Kunal ; Mitra, Analava ; Basak, Amit. / Gelatin-based emulsion gels for diffusion-controlled release applications. In: Journal of Biomaterials Science, Polymer Edition. 2012 ; Vol. 23, No. 5. pp. 645-661.
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Gelatin-based emulsion gels for diffusion-controlled release applications. / Thakur, Goutam; Naqvi, Muhammad Ali; Rousseau, Dérick; Pal, Kunal; Mitra, Analava; Basak, Amit.

In: Journal of Biomaterials Science, Polymer Edition, Vol. 23, No. 5, 22.03.2012, p. 645-661.

Research output: Contribution to journalArticle

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