Gene modulation and immunoregulatory roles of Interferonγ

Banishree Saha, S. Jyothi Prasanna, Bhagawat Chandrasekar, Dipankar Nandi

Research output: Contribution to journalReview article

187 Citations (Scopus)

Abstract

Interferon-gamma (IFNγ) is a central regulator of the immune response and signals via the Janus Activated Kinase (JAK)-Signal Transducer and Activator of Transcription (STAT) pathway. Phosphorylated STAT1 homodimers translocate to the nucleus, bind to Gamma Activating Sequence (GAS) and recruit additional factors to modulate gene expression. A bioinformatics analysis revealed that greater number of putative promoters of immune related genes and also those not directly involved in immunity contain GAS compared to response elements (RE) for Interferon Regulatory Factor (IRF)1, Nuclear factor kappa B (NFκB) and Activator Protein (AP)1. GAS is present in putative promoters of well known IFNγ-induced genes, IRF1, GBP1, CXCL10, and other genes identified were TLR3, VCAM1, CASP4, etc. Analysis of three microarray studies revealed that the expression of a subset of only GAS containing immune genes were modulated by IFNγ. As a significant correlation exists between GAS containing immune genes and IFNγ-regulated gene expression, this strategy may identify novel IFNγ-responsive immune genes. This analysis is integrated with the literature on the roles of IFNγ in mediating a plethora of functions: anti-microbial responses, antigen processing, inflammation, growth suppression, cell death, tumor immunity and autoimmunity. Overall, this review summarizes our present knowledge on IFNγ mediated signaling and functions.

Original languageEnglish
Pages (from-to)1-14
Number of pages14
JournalCytokine
Volume50
Issue number1
DOIs
Publication statusPublished - 01-04-2010

Fingerprint

Interferons
Interferon-gamma
Genes
Modulation
Gene expression
Immunity
Interferon Regulatory Factor-1
Janus Kinases
NF-kappa B
Gene Expression
Transcription Factor AP-1
Response Elements
Cell death
Transcription
Bioinformatics
Microarrays
Antigen Presentation
Microarray Analysis
Computational Biology
Transducers

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Biochemistry
  • Hematology
  • Molecular Biology

Cite this

Saha, Banishree ; Jyothi Prasanna, S. ; Chandrasekar, Bhagawat ; Nandi, Dipankar. / Gene modulation and immunoregulatory roles of Interferonγ. In: Cytokine. 2010 ; Vol. 50, No. 1. pp. 1-14.
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Gene modulation and immunoregulatory roles of Interferonγ. / Saha, Banishree; Jyothi Prasanna, S.; Chandrasekar, Bhagawat; Nandi, Dipankar.

In: Cytokine, Vol. 50, No. 1, 01.04.2010, p. 1-14.

Research output: Contribution to journalReview article

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