Generalised fibrotic gingival enlargement in a psoriatic patient

An association or a coincidence?

Research output: Contribution to journalArticle

Abstract

Gingival fibromatosis is a rare, benign, slow progressive fibrous overgrowth of gingiva, with great genetic and clinical heterogeneity. It can be inherited as an isolated trait (hereditary/idiopathic gingival fibromatosis), and/or as a component of a syndrome. We report a case of a young girl suffering from psoriasis who also presented with an unusual generalised idiopathic gingival fibromatosis. Psoriasis, a chronic inflammatory skin disease, of multifactorial origin, is characterised by keratinocyte hyperproliferation, dedifferentiation, neoangiogenesis and inflammation. T cell-mediated immunity is considered to be the key element in the disease process. The existence of oral mucosal alterations in patients with psoriasis is a controversial topic, as histopathological correlations are not clearly evident, and oral and cutaneous lesions do not follow a parallel course. However, this article highlights a possible association of T-lymphocyte stimulation inducing fibroblasts to undergo epidermal hyperproliferation and increased collagen production in the gingiva, which in turn may be responsible for inducing gingival hyperplasia.

Original languageEnglish
Article number211071
JournalBMJ Case Reports
Volume2015
DOIs
Publication statusPublished - 21-09-2015

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Gingival Fibromatosis
Psoriasis
Gingiva
Gingival Hyperplasia
T-Lymphocytes
Genetic Heterogeneity
Lymphocyte Activation
Keratinocytes
Skin Diseases
Cellular Immunity
Collagen
Fibroblasts
Inflammation
Skin

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

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title = "Generalised fibrotic gingival enlargement in a psoriatic patient: An association or a coincidence?",
abstract = "Gingival fibromatosis is a rare, benign, slow progressive fibrous overgrowth of gingiva, with great genetic and clinical heterogeneity. It can be inherited as an isolated trait (hereditary/idiopathic gingival fibromatosis), and/or as a component of a syndrome. We report a case of a young girl suffering from psoriasis who also presented with an unusual generalised idiopathic gingival fibromatosis. Psoriasis, a chronic inflammatory skin disease, of multifactorial origin, is characterised by keratinocyte hyperproliferation, dedifferentiation, neoangiogenesis and inflammation. T cell-mediated immunity is considered to be the key element in the disease process. The existence of oral mucosal alterations in patients with psoriasis is a controversial topic, as histopathological correlations are not clearly evident, and oral and cutaneous lesions do not follow a parallel course. However, this article highlights a possible association of T-lymphocyte stimulation inducing fibroblasts to undergo epidermal hyperproliferation and increased collagen production in the gingiva, which in turn may be responsible for inducing gingival hyperplasia.",
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Generalised fibrotic gingival enlargement in a psoriatic patient : An association or a coincidence? / Thada, Smitha Rani; Vineetha, Ravindranath; Pai, Keerthilatha M.

In: BMJ Case Reports, Vol. 2015, 211071, 21.09.2015.

Research output: Contribution to journalArticle

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