Generation of an induced pluripotent stem cell line from chorionic villi of a Turner syndrome spontaneous abortion

Shagufta Parveen, M. M. Panicker, Pawan Kumar Gupta

    Research output: Contribution to journalArticlepeer-review

    5 Citations (Scopus)

    Abstract

    A major cause of spontaneous abortions is chromosomal abnormality of foetal cells. We report the generation of an induced pluripotent stem cell line from the fibroblasts isolated from chorionic villi of an early spontaneously aborted foetus with Turner syndrome. The Turner syndrome villus induced pluripotent stem cell line is transgene free, retains the original XO karyotype, expresses pluripotency markers and undergoes trilineage differentiation. This pluripotent stem cell model of Turner syndrome should serve as a tool to study the developmental abnormalities of foetus and placenta that lead to early embryo lethality and profound symptoms like infertility in 45 XO survivors.

    Original languageEnglish
    Pages (from-to)12-16
    Number of pages5
    JournalStem Cell Research
    Volume19
    DOIs
    Publication statusPublished - 01-03-2017

    All Science Journal Classification (ASJC) codes

    • Medicine(all)
    • Developmental Biology
    • Cell Biology

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