Generation of an induced pluripotent stem cell line from chorionic villi of a Turner syndrome spontaneous abortion

Shagufta Parveen, M. M. Panicker, Pawan Kumar Gupta

    Research output: Contribution to journalArticle

    3 Citations (Scopus)

    Abstract

    A major cause of spontaneous abortions is chromosomal abnormality of foetal cells. We report the generation of an induced pluripotent stem cell line from the fibroblasts isolated from chorionic villi of an early spontaneously aborted foetus with Turner syndrome. The Turner syndrome villus induced pluripotent stem cell line is transgene free, retains the original XO karyotype, expresses pluripotency markers and undergoes trilineage differentiation. This pluripotent stem cell model of Turner syndrome should serve as a tool to study the developmental abnormalities of foetus and placenta that lead to early embryo lethality and profound symptoms like infertility in 45 XO survivors.

    Original languageEnglish
    Pages (from-to)12-16
    Number of pages5
    JournalStem Cell Research
    Volume19
    DOIs
    Publication statusPublished - 01-03-2017

    Fingerprint

    Chorionic Villi
    Induced Pluripotent Stem Cells
    Turner Syndrome
    Spontaneous Abortion
    Cell Line
    Aborted Fetus
    Pluripotent Stem Cells
    Transgenes
    Karyotype
    Chromosome Aberrations
    Infertility
    Placenta
    Fetus
    Embryonic Structures
    Fibroblasts

    All Science Journal Classification (ASJC) codes

    • Medicine(all)
    • Developmental Biology
    • Cell Biology

    Cite this

    Parveen, Shagufta ; Panicker, M. M. ; Gupta, Pawan Kumar. / Generation of an induced pluripotent stem cell line from chorionic villi of a Turner syndrome spontaneous abortion. In: Stem Cell Research. 2017 ; Vol. 19. pp. 12-16.
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    Generation of an induced pluripotent stem cell line from chorionic villi of a Turner syndrome spontaneous abortion. / Parveen, Shagufta; Panicker, M. M.; Gupta, Pawan Kumar.

    In: Stem Cell Research, Vol. 19, 01.03.2017, p. 12-16.

    Research output: Contribution to journalArticle

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