Genetic similarities between tobacco use disorder and related comorbidities

An exploratory study

Sylviane de Viron, Servaas A. Morré, Herman Van Oyen, Angela Brand, Sander Ouburg

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: Tobacco use disorder (TUD), defined as the use of tobacco to the detriment of a person's health or social functioning, is associated with various disorders. We hypothesized that mutual variation in genes may partly explain this link. The aims of this study were to make a non-exhaustive inventory of the disorders using (partially) the same genetic pathways as TUD, and to describe the genetic similarities between TUD and the selected disorders. Methods: We developed a 3 stage approach: (i) selection of genes influencing TUD using Gene2Mesh and Ingenuity Pathway Analysis (IPA), (ii) selection of disorders associated with the selected genes using IPA and (iii) genetic similarities between disorders associated with TUD using Jaccard distance and cluster analyses. Results: Fourteen disorders and thirty-two genes met our inclusion criteria. The Jaccard distance between pairs of disorders ranged from 0.00 (e.g. oesophageal cancer and malignant hypertension) to 0.45 (e.g. bladder cancer and addiction). A lower number in the Jaccard distance indicates a higher similarity between the two disorders. Two main clusters of genetically similar disorders were observed, one including coexisting disorders (e.g. addiction and alcoholism) and the other one with the side-effects of smoking (e.g. gastric cancer and malignant hypertension). Conclusions: This exploratory study partly explains the potential genetic components linking TUD to other disorders. Two principle clusters of disorders were observed (i) coexisting disorders of TUD and (ii) side-effects of TUD disorders. A further deepening of this observation in a real life study should allow strengthening this hypothesis.

Original languageEnglish
Article number85
JournalBMC Medical Genetics
Volume15
Issue number1
DOIs
Publication statusPublished - 24-07-2014

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Tobacco Use Disorder
Comorbidity
Malignant Hypertension
Genes
Tobacco Use
Esophageal Neoplasms
Urinary Bladder Neoplasms
Alcoholism
Stomach Neoplasms
Cluster Analysis
Smoking
Equipment and Supplies
Health

All Science Journal Classification (ASJC) codes

  • Genetics(clinical)
  • Genetics

Cite this

de Viron, Sylviane ; Morré, Servaas A. ; Van Oyen, Herman ; Brand, Angela ; Ouburg, Sander. / Genetic similarities between tobacco use disorder and related comorbidities : An exploratory study. In: BMC Medical Genetics. 2014 ; Vol. 15, No. 1.
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Genetic similarities between tobacco use disorder and related comorbidities : An exploratory study. / de Viron, Sylviane; Morré, Servaas A.; Van Oyen, Herman; Brand, Angela; Ouburg, Sander.

In: BMC Medical Genetics, Vol. 15, No. 1, 85, 24.07.2014.

Research output: Contribution to journalArticle

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AU - Ouburg, Sander

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