Genotype-based prevention of psychosis onset and schizophrenia: A personalized approach in a target population

Bahar Taneri, Mevhibe B. Hocaoglu, Angela Brand, Jim Van Os

Research output: Contribution to journalArticle

1 Citation (Scopus)


Schizophrenia imposes a significant burden on public health, affecting approximately 25 million individuals worldwide and generating an extensive healthcare burden. It is important to consider that the disease onset in schizophrenia stems from gene-environment interactions. Early interventions in order to prevent schizophrenia are of high clinical interest, and this is where personalized healthcare and medicine comes in. In this article, we bring a genotype-based personalized, preventive perspective to psychosis onset and schizophrenia. Our objective relies on the possibility of making use of a specific gene-environment interaction in the emergence of schizophrenia as a personalized preventive tool. In particular, we discuss screening of a specific AKT1 allelic variation and its interaction with cannabis use as a preventive approach in a target population with early symptoms of psychosis.

Original languageEnglish
Pages (from-to)167-172
Number of pages6
JournalPersonalized Medicine
Issue number2
Publication statusPublished - 2014


All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Molecular Medicine
  • Pharmacology

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