Geographical distribution of primary & secondary dengue cases in India-2017: A cross-sectional multicentric study

Chaitra Rao, Harmanmeet Kaur, Nivedita Gupta, Sasidharan Pillai Sabeena, R. Ambica, Amita Jain, Ashvini Yadav, Bhagirathi Dwibedi, Bharti Malhotra, Dalip Kakru, Debasis Biswas, Deepali Savargaonkar, M. Ganesan, Jyotsnamayee Sabat, Kanwardeep Dhingra, S. Lalitha, Neena Valecha, Pamireddy Madhavilatha, Pradip V. Barde, Piyush D. JoshiPratibha Sharma, Rajarshi Gupta, R. K. Ratho, Shailpreet Sidhu, Shakti Saumnam Shrivastava, Shanta Dutta, G. Shantala, Sheikh Imtiaz, Shveta Sethi, Usha Kalawat, P. Vijayachari, Vimal Raj, Neetu Vijay, Biswajyoti Borkakoty, Purnima Barua, Tapan Majumdar, Govindakarnavar Arunkumar

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Background & objectives: Dengue virus infection is endemic in India with all the four serotypes of dengue virus in circulation. This study was aimed to determine the geographic distribution of the primary and secondary dengue cases in India. Methods: A multicentre cross-sectional study was conducted at Department of Health Research / Indian Council of Medical Research (DHR)/(ICMR) viral research and diagnostic laboratories (VRDLs) and selected ICMR institutes located in India. Only laboratory-confirmed dengue cases with date of onset of illness less than or equal to seven days were included between September and October 2017. Dengue NS1 antigen ELISA and anti-dengue IgM capture ELISA were used to diagnose dengue cases while anti-dengue IgG capture ELISA was used for identifying the secondary dengue cases. Results: Of the 1372 dengue cases, 897 (65%) were classified as primary dengue and 475 (35%) as secondary dengue cases. However, the proportion varied widely geographically, with Theni, Tamil Nadu; Tirupati, Andhra Pradesh and Udupi-Manipal, Karnataka reporting more than 65 per cent secondary dengue cases while Srinagar, Jammu and Kashmir reporting as low as 10 per cent of the same. The median age of primary dengue cases was 25 yr [interquartile range (IQR 17-35] while that of secondary dengue cases was 23 yr (IQR 13.5-34). Secondary dengue was around 50 per cent among the children belonging to the age group 6-10 yr while it ranged between 20-43 per cent among other age groups. Interpretation & conclusions: Our findings showed a wide geographical variation in the distribution of primary and secondary dengue cases in India. It would prove beneficial to include primary and secondary dengue differentiation protocol in the national dengue surveillance programme.

Original languageEnglish
Pages (from-to)548-553
Number of pages6
JournalIndian Journal of Medical Research
Volume149
Issue number4
DOIs
Publication statusPublished - 01-04-2019

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint Dive into the research topics of 'Geographical distribution of primary & secondary dengue cases in India-2017: A cross-sectional multicentric study'. Together they form a unique fingerprint.

Cite this