Geographical distribution of primary & secondary dengue cases in India-2017

A cross-sectional multicentric study

Chaitra Rao, Harmanmeet Kaur, Nivedita Gupta, Sasidharan Pillai Sabeena, R. Ambica, Amita Jain, Ashvini Yadav, Bhagirathi Dwibedi, Bharti Malhotra, Dalip Kakru, Debasis Biswas, Deepali Savargaonkar, M. Ganesan, Jyotsnamayee Sabat, Kanwardeep Dhingra, S. Lalitha, Neena Valecha, Pamireddy Madhavilatha, Pradip V. Barde, Piyush D. Joshi & 17 others Pratibha Sharma, Rajarshi Gupta, R. K. Ratho, Shailpreet Sidhu, Shakti Saumnam Shrivastava, Shanta Dutta, G. Shantala, Sheikh Imtiaz, Shveta Sethi, Usha Kalawat, P. Vijayachari, Vimal Raj, Neetu Vijay, Biswajyoti Borkakoty, Purnima Barua, Tapan Majumdar, Govindakarnavar Arunkumar

Research output: Contribution to journalArticle

Abstract

Background & objectives: Dengue virus infection is endemic in India with all the four serotypes of dengue virus in circulation. This study was aimed to determine the geographic distribution of the primary and secondary dengue cases in India. Methods: A multicentre cross-sectional study was conducted at Department of Health Research / Indian Council of Medical Research (DHR)/(ICMR) viral research and diagnostic laboratories (VRDLs) and selected ICMR institutes located in India. Only laboratory-confirmed dengue cases with date of onset of illness less than or equal to seven days were included between September and October 2017. Dengue NS1 antigen ELISA and anti-dengue IgM capture ELISA were used to diagnose dengue cases while anti-dengue IgG capture ELISA was used for identifying the secondary dengue cases. Results: Of the 1372 dengue cases, 897 (65%) were classified as primary dengue and 475 (35%) as secondary dengue cases. However, the proportion varied widely geographically, with Theni, Tamil Nadu; Tirupati, Andhra Pradesh and Udupi-Manipal, Karnataka reporting more than 65 per cent secondary dengue cases while Srinagar, Jammu and Kashmir reporting as low as 10 per cent of the same. The median age of primary dengue cases was 25 yr [interquartile range (IQR 17-35] while that of secondary dengue cases was 23 yr (IQR 13.5-34). Secondary dengue was around 50 per cent among the children belonging to the age group 6-10 yr while it ranged between 20-43 per cent among other age groups. Interpretation & conclusions: Our findings showed a wide geographical variation in the distribution of primary and secondary dengue cases in India. It would prove beneficial to include primary and secondary dengue differentiation protocol in the national dengue surveillance programme.

Original languageEnglish
Pages (from-to)548-553
Number of pages6
JournalIndian Journal of Medical Research
Volume149
Issue number4
DOIs
Publication statusPublished - 01-04-2019

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Geographical distribution
Dengue
India
Cross-Sectional Studies
Viruses
Immunoglobulin M
Immunoglobulin G
Health
Antigens
Dengue Virus
Enzyme-Linked Immunosorbent Assay
Age Groups

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Rao, Chaitra ; Kaur, Harmanmeet ; Gupta, Nivedita ; Sabeena, Sasidharan Pillai ; Ambica, R. ; Jain, Amita ; Yadav, Ashvini ; Dwibedi, Bhagirathi ; Malhotra, Bharti ; Kakru, Dalip ; Biswas, Debasis ; Savargaonkar, Deepali ; Ganesan, M. ; Sabat, Jyotsnamayee ; Dhingra, Kanwardeep ; Lalitha, S. ; Valecha, Neena ; Madhavilatha, Pamireddy ; Barde, Pradip V. ; Joshi, Piyush D. ; Sharma, Pratibha ; Gupta, Rajarshi ; Ratho, R. K. ; Sidhu, Shailpreet ; Shrivastava, Shakti Saumnam ; Dutta, Shanta ; Shantala, G. ; Imtiaz, Sheikh ; Sethi, Shveta ; Kalawat, Usha ; Vijayachari, P. ; Raj, Vimal ; Vijay, Neetu ; Borkakoty, Biswajyoti ; Barua, Purnima ; Majumdar, Tapan ; Arunkumar, Govindakarnavar. / Geographical distribution of primary & secondary dengue cases in India-2017 : A cross-sectional multicentric study. In: Indian Journal of Medical Research. 2019 ; Vol. 149, No. 4. pp. 548-553.
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Rao, C, Kaur, H, Gupta, N, Sabeena, SP, Ambica, R, Jain, A, Yadav, A, Dwibedi, B, Malhotra, B, Kakru, D, Biswas, D, Savargaonkar, D, Ganesan, M, Sabat, J, Dhingra, K, Lalitha, S, Valecha, N, Madhavilatha, P, Barde, PV, Joshi, PD, Sharma, P, Gupta, R, Ratho, RK, Sidhu, S, Shrivastava, SS, Dutta, S, Shantala, G, Imtiaz, S, Sethi, S, Kalawat, U, Vijayachari, P, Raj, V, Vijay, N, Borkakoty, B, Barua, P, Majumdar, T & Arunkumar, G 2019, 'Geographical distribution of primary & secondary dengue cases in India-2017: A cross-sectional multicentric study', Indian Journal of Medical Research, vol. 149, no. 4, pp. 548-553. https://doi.org/10.4103/ijmr.IJMR_916_18

Geographical distribution of primary & secondary dengue cases in India-2017 : A cross-sectional multicentric study. / Rao, Chaitra; Kaur, Harmanmeet; Gupta, Nivedita; Sabeena, Sasidharan Pillai; Ambica, R.; Jain, Amita; Yadav, Ashvini; Dwibedi, Bhagirathi; Malhotra, Bharti; Kakru, Dalip; Biswas, Debasis; Savargaonkar, Deepali; Ganesan, M.; Sabat, Jyotsnamayee; Dhingra, Kanwardeep; Lalitha, S.; Valecha, Neena; Madhavilatha, Pamireddy; Barde, Pradip V.; Joshi, Piyush D.; Sharma, Pratibha; Gupta, Rajarshi; Ratho, R. K.; Sidhu, Shailpreet; Shrivastava, Shakti Saumnam; Dutta, Shanta; Shantala, G.; Imtiaz, Sheikh; Sethi, Shveta; Kalawat, Usha; Vijayachari, P.; Raj, Vimal; Vijay, Neetu; Borkakoty, Biswajyoti; Barua, Purnima; Majumdar, Tapan; Arunkumar, Govindakarnavar.

In: Indian Journal of Medical Research, Vol. 149, No. 4, 01.04.2019, p. 548-553.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Geographical distribution of primary & secondary dengue cases in India-2017

T2 - A cross-sectional multicentric study

AU - Rao, Chaitra

AU - Kaur, Harmanmeet

AU - Gupta, Nivedita

AU - Sabeena, Sasidharan Pillai

AU - Ambica, R.

AU - Jain, Amita

AU - Yadav, Ashvini

AU - Dwibedi, Bhagirathi

AU - Malhotra, Bharti

AU - Kakru, Dalip

AU - Biswas, Debasis

AU - Savargaonkar, Deepali

AU - Ganesan, M.

AU - Sabat, Jyotsnamayee

AU - Dhingra, Kanwardeep

AU - Lalitha, S.

AU - Valecha, Neena

AU - Madhavilatha, Pamireddy

AU - Barde, Pradip V.

AU - Joshi, Piyush D.

AU - Sharma, Pratibha

AU - Gupta, Rajarshi

AU - Ratho, R. K.

AU - Sidhu, Shailpreet

AU - Shrivastava, Shakti Saumnam

AU - Dutta, Shanta

AU - Shantala, G.

AU - Imtiaz, Sheikh

AU - Sethi, Shveta

AU - Kalawat, Usha

AU - Vijayachari, P.

AU - Raj, Vimal

AU - Vijay, Neetu

AU - Borkakoty, Biswajyoti

AU - Barua, Purnima

AU - Majumdar, Tapan

AU - Arunkumar, Govindakarnavar

PY - 2019/4/1

Y1 - 2019/4/1

N2 - Background & objectives: Dengue virus infection is endemic in India with all the four serotypes of dengue virus in circulation. This study was aimed to determine the geographic distribution of the primary and secondary dengue cases in India. Methods: A multicentre cross-sectional study was conducted at Department of Health Research / Indian Council of Medical Research (DHR)/(ICMR) viral research and diagnostic laboratories (VRDLs) and selected ICMR institutes located in India. Only laboratory-confirmed dengue cases with date of onset of illness less than or equal to seven days were included between September and October 2017. Dengue NS1 antigen ELISA and anti-dengue IgM capture ELISA were used to diagnose dengue cases while anti-dengue IgG capture ELISA was used for identifying the secondary dengue cases. Results: Of the 1372 dengue cases, 897 (65%) were classified as primary dengue and 475 (35%) as secondary dengue cases. However, the proportion varied widely geographically, with Theni, Tamil Nadu; Tirupati, Andhra Pradesh and Udupi-Manipal, Karnataka reporting more than 65 per cent secondary dengue cases while Srinagar, Jammu and Kashmir reporting as low as 10 per cent of the same. The median age of primary dengue cases was 25 yr [interquartile range (IQR 17-35] while that of secondary dengue cases was 23 yr (IQR 13.5-34). Secondary dengue was around 50 per cent among the children belonging to the age group 6-10 yr while it ranged between 20-43 per cent among other age groups. Interpretation & conclusions: Our findings showed a wide geographical variation in the distribution of primary and secondary dengue cases in India. It would prove beneficial to include primary and secondary dengue differentiation protocol in the national dengue surveillance programme.

AB - Background & objectives: Dengue virus infection is endemic in India with all the four serotypes of dengue virus in circulation. This study was aimed to determine the geographic distribution of the primary and secondary dengue cases in India. Methods: A multicentre cross-sectional study was conducted at Department of Health Research / Indian Council of Medical Research (DHR)/(ICMR) viral research and diagnostic laboratories (VRDLs) and selected ICMR institutes located in India. Only laboratory-confirmed dengue cases with date of onset of illness less than or equal to seven days were included between September and October 2017. Dengue NS1 antigen ELISA and anti-dengue IgM capture ELISA were used to diagnose dengue cases while anti-dengue IgG capture ELISA was used for identifying the secondary dengue cases. Results: Of the 1372 dengue cases, 897 (65%) were classified as primary dengue and 475 (35%) as secondary dengue cases. However, the proportion varied widely geographically, with Theni, Tamil Nadu; Tirupati, Andhra Pradesh and Udupi-Manipal, Karnataka reporting more than 65 per cent secondary dengue cases while Srinagar, Jammu and Kashmir reporting as low as 10 per cent of the same. The median age of primary dengue cases was 25 yr [interquartile range (IQR 17-35] while that of secondary dengue cases was 23 yr (IQR 13.5-34). Secondary dengue was around 50 per cent among the children belonging to the age group 6-10 yr while it ranged between 20-43 per cent among other age groups. Interpretation & conclusions: Our findings showed a wide geographical variation in the distribution of primary and secondary dengue cases in India. It would prove beneficial to include primary and secondary dengue differentiation protocol in the national dengue surveillance programme.

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SP - 548

EP - 553

JO - Indian Journal of Medical Research

JF - Indian Journal of Medical Research

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