TY - JOUR
T1 - Geographical distribution of primary & secondary dengue cases in India-2017
T2 - A cross-sectional multicentric study
AU - Rao, Chaitra
AU - Kaur, Harmanmeet
AU - Gupta, Nivedita
AU - Sabeena, Sasidharan Pillai
AU - Ambica, R.
AU - Jain, Amita
AU - Yadav, Ashvini
AU - Dwibedi, Bhagirathi
AU - Malhotra, Bharti
AU - Kakru, Dalip
AU - Biswas, Debasis
AU - Savargaonkar, Deepali
AU - Ganesan, M.
AU - Sabat, Jyotsnamayee
AU - Dhingra, Kanwardeep
AU - Lalitha, S.
AU - Valecha, Neena
AU - Madhavilatha, Pamireddy
AU - Barde, Pradip V.
AU - Joshi, Piyush D.
AU - Sharma, Pratibha
AU - Gupta, Rajarshi
AU - Ratho, R. K.
AU - Sidhu, Shailpreet
AU - Shrivastava, Shakti Saumnam
AU - Dutta, Shanta
AU - Shantala, G.
AU - Imtiaz, Sheikh
AU - Sethi, Shveta
AU - Kalawat, Usha
AU - Vijayachari, P.
AU - Raj, Vimal
AU - Vijay, Neetu
AU - Borkakoty, Biswajyoti
AU - Barua, Purnima
AU - Majumdar, Tapan
AU - Arunkumar, Govindakarnavar
PY - 2019/4/1
Y1 - 2019/4/1
N2 - Background & objectives: Dengue virus infection is endemic in India with all the four serotypes of dengue virus in circulation. This study was aimed to determine the geographic distribution of the primary and secondary dengue cases in India. Methods: A multicentre cross-sectional study was conducted at Department of Health Research / Indian Council of Medical Research (DHR)/(ICMR) viral research and diagnostic laboratories (VRDLs) and selected ICMR institutes located in India. Only laboratory-confirmed dengue cases with date of onset of illness less than or equal to seven days were included between September and October 2017. Dengue NS1 antigen ELISA and anti-dengue IgM capture ELISA were used to diagnose dengue cases while anti-dengue IgG capture ELISA was used for identifying the secondary dengue cases. Results: Of the 1372 dengue cases, 897 (65%) were classified as primary dengue and 475 (35%) as secondary dengue cases. However, the proportion varied widely geographically, with Theni, Tamil Nadu; Tirupati, Andhra Pradesh and Udupi-Manipal, Karnataka reporting more than 65 per cent secondary dengue cases while Srinagar, Jammu and Kashmir reporting as low as 10 per cent of the same. The median age of primary dengue cases was 25 yr [interquartile range (IQR 17-35] while that of secondary dengue cases was 23 yr (IQR 13.5-34). Secondary dengue was around 50 per cent among the children belonging to the age group 6-10 yr while it ranged between 20-43 per cent among other age groups. Interpretation & conclusions: Our findings showed a wide geographical variation in the distribution of primary and secondary dengue cases in India. It would prove beneficial to include primary and secondary dengue differentiation protocol in the national dengue surveillance programme.
AB - Background & objectives: Dengue virus infection is endemic in India with all the four serotypes of dengue virus in circulation. This study was aimed to determine the geographic distribution of the primary and secondary dengue cases in India. Methods: A multicentre cross-sectional study was conducted at Department of Health Research / Indian Council of Medical Research (DHR)/(ICMR) viral research and diagnostic laboratories (VRDLs) and selected ICMR institutes located in India. Only laboratory-confirmed dengue cases with date of onset of illness less than or equal to seven days were included between September and October 2017. Dengue NS1 antigen ELISA and anti-dengue IgM capture ELISA were used to diagnose dengue cases while anti-dengue IgG capture ELISA was used for identifying the secondary dengue cases. Results: Of the 1372 dengue cases, 897 (65%) were classified as primary dengue and 475 (35%) as secondary dengue cases. However, the proportion varied widely geographically, with Theni, Tamil Nadu; Tirupati, Andhra Pradesh and Udupi-Manipal, Karnataka reporting more than 65 per cent secondary dengue cases while Srinagar, Jammu and Kashmir reporting as low as 10 per cent of the same. The median age of primary dengue cases was 25 yr [interquartile range (IQR 17-35] while that of secondary dengue cases was 23 yr (IQR 13.5-34). Secondary dengue was around 50 per cent among the children belonging to the age group 6-10 yr while it ranged between 20-43 per cent among other age groups. Interpretation & conclusions: Our findings showed a wide geographical variation in the distribution of primary and secondary dengue cases in India. It would prove beneficial to include primary and secondary dengue differentiation protocol in the national dengue surveillance programme.
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U2 - 10.4103/ijmr.IJMR_916_18
DO - 10.4103/ijmr.IJMR_916_18
M3 - Article
AN - SCOPUS:85070475806
SN - 0971-5916
VL - 149
SP - 548
EP - 553
JO - Indian Journal of Medical Research
JF - Indian Journal of Medical Research
IS - 4
ER -
