Glipizide matrix transdermal systems for diabetes mellitus: Preparation, in vitro and preclinical studies

Srinivas Mutalik, Nayanabhirama Udupa, Sharath Kumar, Sunil Agarwal, Ganesh Subramanian, Averineni K. Ranjith

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

The aim of the present investigation was to prepare glipizide matrix transdermal systems using the combinations of ethyl cellulose/polyvinylpyrrolidone and Eudragit RL-100/Eudragit RS-100. The systems were evaluated for various in vitro (drug content, drug permeation, scanning electron microscopy and drug-polymer interactions) and in vivo (acute and long-term hypoglycemic activity, biochemical and histopathological studies, skin irritation and pharmacokinetic studies in mice) parameters. Drug content of the patches was found to be more than 98%. Variations in drug permeation profiles were observed among various formulations. The scanning electron microscopy of the patches showed the formation of pores on the surface after in vitro permeation studies. The drug-polymer interaction results suggested no interaction between drug and polymers. The in vivo results revealed that the patches successfully prevented the severe hypoglycemia in the initial hours and they were also effective on chronic application. The transdermal route exhibited negligible skin irritation and produced better improvement with all the tested in vivo parameters compared to oral administration.

Original languageEnglish
Pages (from-to)1568-1577
Number of pages10
JournalLife Sciences
Volume79
Issue number16
DOIs
Publication statusPublished - 13-09-2006

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Glipizide
Medical problems
Diabetes Mellitus
Drug Interactions
Polymers
Permeation
Pharmaceutical Preparations
Electron Scanning Microscopy
Povidone
Skin
Hypoglycemia
Hypoglycemic Agents
Drug interactions
Oral Administration
Scanning electron microscopy
Pharmacokinetics
In Vitro Techniques

All Science Journal Classification (ASJC) codes

  • Pharmacology

Cite this

Mutalik, Srinivas ; Udupa, Nayanabhirama ; Kumar, Sharath ; Agarwal, Sunil ; Subramanian, Ganesh ; Ranjith, Averineni K. / Glipizide matrix transdermal systems for diabetes mellitus : Preparation, in vitro and preclinical studies. In: Life Sciences. 2006 ; Vol. 79, No. 16. pp. 1568-1577.
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Glipizide matrix transdermal systems for diabetes mellitus : Preparation, in vitro and preclinical studies. / Mutalik, Srinivas; Udupa, Nayanabhirama; Kumar, Sharath; Agarwal, Sunil; Subramanian, Ganesh; Ranjith, Averineni K.

In: Life Sciences, Vol. 79, No. 16, 13.09.2006, p. 1568-1577.

Research output: Contribution to journalArticle

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