Global mortality from dementia: Application of a newmethod and results from the global burden of disease study 2019

Emma Nichols, Foad Abd-Allah, Amir Abdoli, Akine Eshete Abosetugn, Woldu Aberhe Abrha, Ahmed Abualhasan, Eman Abu-Gharbieh, Rufus Olusola Akinyemi, Fares Alahdab, Fahad Mashhour Alanezi, Vahid Alipour, Iman Ansari, Jalal Arabloo, Amir Ashraf-Ganjouei, Abolfazl Avan, Getinet Ayano, Zaheer Ud Din Babar, Atif Amin Baig, Maciej Banach, Miguel A. BarbozaSuzanne Lyn Barker-Collo, Bernhard T. Baune, Akshaya Srikanth Bhagavathula, Krittika Bhattacharyya, Ali Bijani, Antonio Biondi, Tsegaye Adane Birhan, Atanu Biswas, Srinivasa Rao Bolla, Archith Boloor, Carol Brayne, Hermann Brenner, Katrin Burkart, Richard A. Burns, Sharath Burugina Nagaraja, Felix Carvalho, Luis F.S. Castro-De-araujo, Ferrán Catalá-López, Ester Cerin, Achille Cernigliaro, Nicolas Cherbuin, Jee Young Jasmine Choi, Dinh Toi Chu, Baye Dagnew, Xiaochen Dai, Lalit Dandona, Rakhi Dandona, Daniel Diaz, Zahra Sadat Dibaji Forooshani, Abdel Douiri, Bruce B. Duncan, David Edvardsson, Shaimaa I. El-Jaafary, Khalil Eskandari, Sharareh Eskandarieh, Valery L. Feigin, Seyed Mohammad Fereshtehnejad, Eduarda Fernandes, Pietro Ferrara, Irina Filip, Florian Fischer, Shilpa Gaidhane, Kidane Zereabruk Gebregzabiher, Ahmad Ghashghaee, Asadollah Gholamian, Elena V. Gnedovskaya, Mahaveer Golechha, Rajeev Gupta, Vladimir Hachinski, Samer Hamidi, Graeme J. Hankey, Josep Maria Haro, Amr Hassan, Simon I. Hay, Golnaz Heidari, Reza Heidari-Soureshjani, Mowafa Househ, Rabia Hussain, Bing Fang Hwang, Irena M. Ilic, Milena D. Ilic, Seyed Sina Naghibi Irvani, Hiroyasu Iso, Masao Iwagami, Ravi Prakash Jha, Rizwan Kalani, Himal Kandel, André Karch, Ayele Semachew Kasa, Andre Pascal Kengne, Young Eun Kim, Yun Jin Kim, Sezer Kisa, Adnan Kisa, Mika Kivimäki, Hamidreza Komaki, Aikoyanagi, Walter A. Kukull, G. Anil Kumar, Manasi Kumar, Iván Landires, Matilde Leonardi, Stephen S. Lim, Xuefeng Liu, Giancarlo Logroscino, Alan D. Lopez, Stefan Lorkowski, Clement T. Loy, Hawraz Ibrahim M. Amin, Navid Manafi, Narayana Manjunatha, Man Mohan Mehndiratta, Ritesh G. Menezes, Atte Meretoja, Alexander Merkin, Workua Mekonnen Metekiya, Awoke Temesgen Misganaw, Bahram Mohajer, Norlinah Mohamed Ibrahim, Yousef Mohammad, Archisman Mohapatra, Farnam Mohebi, Ali H. Mokdad, Stefania Mondello, Tilahun Belete Mossie, Anwar Mulugeta, Gabriele Nagel, Muhammad Naveed, Vinod C. Nayak, Sandhya Neupane Kandel, Son Hoang Nguyen, Huong Lan Thi Nguyen, Virginia Nuñez-Samudio, Felix Akpojene Ogbo, Andrew T. Olagunju, Hans Orru, Sergej M. Ostojic, Samuel M. Ostroff, Nikita Otstavnov, Stanislav S. Otstavnov, Mayowa O. Owolabi, Mona Pathak, Hamidreza Pazoki Toroudi, Carrie B. Peterson, Hai Quang Pham, Michael R. Phillips, Michael A. Piradov, Faheem Hyder Pottoo, Sergio I. Prada, Dimas Ria Angga Pribadi, Amir Radfar, Alberto Raggi, Fakher Rahim, Pradhum Ram, Juwel Rana, Vahid Rashedi, Salman Rawaf, David Laith Rawaf, Nickolas Reinig, Nima Rezaei, Stephen R. Robinson, Michele Romoli, Perminder S. Sachdev, Ramesh Sahathevan, Amirhossein Sahebkar, Mohammad Ali Sahraian, Davide Sattin, Mete Saylan, Mehdi Sayyah, Silvia Schiavolin, Maria Inês Schmidt, Izza Shahid, Masood Ali Shaikh, Mika Shigematsu, Jae Il Shin, Rahman Shiri, Tariq Jamal Siddiqi, João Pedro Silva, Jasvinder A. Singh, Amin Soheili, Emma Elizabeth Spurlock, Cassandra E.I. Szoeke, Rafael Tabarés-Seisdedos, Biruk Wogayehu Taddele, Bhaskar Thakur, Akhil Soman Thekke Purakkal, Marcos Roberto Tovani-Palone, Bach Xuan Tran, Ravensara S. Travillian, Manjari Tripathi, Gebiyaw Wudie Tsegaye, Muhammad Shariq Usman, Marco Vacante, Diana Zuleika Velazquez, Narayanaswamy Venketasubramanian, Simone Vidale, Vasily Vlassov, Yuan Pang Wang, Jingkai Wei, Jordan Weiss, Abrha Hailay Weldemariam, Anders Wimo, Chenkai Wu, Ali Yadollahpour, Kazumasa Yamagishi, Yordanos Gizachew Yeshitila, Naohiro Yonemoto, Siddhesh Zadey, Zhi Jiang Zhang, Christopher J.L. Murray, Theo Vos

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12 Citations (Scopus)

Abstract

Introduction: Dementia is currently one of the leading causes of mortality globally, and mortality due to dementia will likely increase in the future along with corresponding increases in population growth and population aging. However, large inconsistencies in coding practices in vital registration systems over time and between countries complicate the estimation of global dementia mortality. Methods: We meta-analyzed the excess risk of death in those with dementia and multiplied these estimates by the proportion of dementia deaths occurring in those with severe, end-stage disease to calculate the total number of deaths that could be attributed to dementia. Results: We estimated that there were 1.62 million (95% uncertainty interval [UI]: 0.41-4.21) deaths globally due to dementia in 2019. More dementia deaths occurred in women (1.06 million [0.27-2.71]) than men (0.56 million [0.14-1.51]), largely but not entirely due to the higher life expectancy in women (age-standardized female-tomale ratio 1.19 [1.10-1.26]). Due to population aging, there was a large increase in allage mortality rates from dementia between 1990 and 2019 (100.1% [89.1-117.5]). In 2019, deaths due to dementia ranked seventh globally in all ages and fourth among individuals 70 and older compared to deaths from other diseases estimated in the Global Burden of Disease (GBD) study. Discussion: Mortality due to dementia represents a substantial global burden, and is expected to continue to grow into the future as an older, aging population expands globally.

Original languageEnglish
Article numbere12200
JournalAlzheimer's and Dementia: Translational Research and Clinical Interventions
Volume7
Issue number1
DOIs
Publication statusPublished - 2021

All Science Journal Classification (ASJC) codes

  • Clinical Neurology
  • Psychiatry and Mental health

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