Global protein sequence variation in HIV-1-b isolates derived from human blood and brain

Seetharaman Balaji, Patil Sneha, Murugappan Rama, Paul Shapshak

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Citations (Scopus)

Abstract

The first part of this chapter introduces the proteins encoded by HIV-1. Their consensus sequences, structures, and functions are discussed. Amino acid sequence variations due to different selective pressures that drive the evolution of HIV-1 including compartmentalization and geographical variations are addressed. Sequence and phylogenetic analysis are used to identify conserved as well as variable regions of HIV-1-B isolates derived from human blood and brain. These signature sequences may have a significant impact on future vaccine design and development.

Original languageEnglish
Title of host publicationGlobal Virology I-Identifying and Investigating Viral Diseases
PublisherSpringer New York
Pages613-666
Number of pages54
ISBN (Electronic)9781493924103
ISBN (Print)9781493924097
DOIs
Publication statusPublished - 01-01-2015
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Immunology and Microbiology(all)

Cite this

Balaji, S., Sneha, P., Rama, M., & Shapshak, P. (2015). Global protein sequence variation in HIV-1-b isolates derived from human blood and brain. In Global Virology I-Identifying and Investigating Viral Diseases (pp. 613-666). Springer New York. https://doi.org/10.1007/978-1-4939-2410-3_24