The first part of this chapter introduces the proteins encoded by HIV-1. Their consensus sequences, structures, and functions are discussed. Amino acid sequence variations due to different selective pressures that drive the evolution of HIV-1 including compartmentalization and geographical variations are addressed. Sequence and phylogenetic analysis are used to identify conserved as well as variable regions of HIV-1-B isolates derived from human blood and brain. These signature sequences may have a significant impact on future vaccine design and development.
|Title of host publication||Global Virology I-Identifying and Investigating Viral Diseases|
|Publisher||Springer New York|
|Number of pages||54|
|Publication status||Published - 01-01-2015|
All Science Journal Classification (ASJC) codes
- Immunology and Microbiology(all)