Glutaraldehyde cross-linked chitosan microspheres for controlled delivery of Zidovudine

Usha Yogendra Nayak, Shavi Gopal, Srinivas Mutalik, Averinen Kumar Ranjith, Meka Sreenivasa Reddy, Purushotham Gupta, Nayanabhirama Udupa

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Zidovudine-Chitosan microspheres were prepared by a suspension cross-linking method. The chitosan was dissolved in 2 acetic acid solution and this solution was dispersed in the light liquid paraffin. Span-80 was used as an emulsifier and glutaraldehyde as cross-linking agent. The prepared microspheres were slight yellow, free flowing and characterized by drug loading, infrared spectroscopy (IR), differential scanning colorimetry (DSC) and scanning electron microscopy (SEM). The in-vitro release studies are performed in pH 7.4 buffer solution. Microspheres produced are spherical and have smooth surfaces, with sizes ranging between 60210 m, as evidenced by SEM and particle size analysis. The drug loaded microspheres showed up to 60 of entrapment and release was extended up to 1824 h. Among all the systems studied, the 35 Glutaraldehyde crosslinked, microspheres with 1 : 6 drug/chitosan ratio showed 75 release at 12 h. The infrared spectra and DSC thermograms showed stable character of zidovudine in the drug loaded microspheres and revealed the absence of drugpolymer interactions. Data obtained from in vitro release were fitted to various kinetic models and high correlation was obtained in the Higuchi model. The drug release was found to be diffusion controlled.

Original languageEnglish
Pages (from-to)214-222
Number of pages9
JournalJournal of Microencapsulation
Volume26
Issue number3
DOIs
Publication statusPublished - 05-2009

Fingerprint

Zidovudine
Chitosan
Glutaral
Microspheres
delivery
drugs
colorimetry
Colorimetry
Pharmaceutical Preparations
Electron Scanning Microscopy
thermograms
scanning electron microscopy
scanning
entrapment
Scanning
paraffins
Mineral Oil
Scanning electron microscopy
acetic acid
Particle Size

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Pharmaceutical Science
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Colloid and Surface Chemistry

Cite this

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abstract = "Zidovudine-Chitosan microspheres were prepared by a suspension cross-linking method. The chitosan was dissolved in 2 acetic acid solution and this solution was dispersed in the light liquid paraffin. Span-80 was used as an emulsifier and glutaraldehyde as cross-linking agent. The prepared microspheres were slight yellow, free flowing and characterized by drug loading, infrared spectroscopy (IR), differential scanning colorimetry (DSC) and scanning electron microscopy (SEM). The in-vitro release studies are performed in pH 7.4 buffer solution. Microspheres produced are spherical and have smooth surfaces, with sizes ranging between 60210 m, as evidenced by SEM and particle size analysis. The drug loaded microspheres showed up to 60 of entrapment and release was extended up to 1824 h. Among all the systems studied, the 35 Glutaraldehyde crosslinked, microspheres with 1 : 6 drug/chitosan ratio showed 75 release at 12 h. The infrared spectra and DSC thermograms showed stable character of zidovudine in the drug loaded microspheres and revealed the absence of drugpolymer interactions. Data obtained from in vitro release were fitted to various kinetic models and high correlation was obtained in the Higuchi model. The drug release was found to be diffusion controlled.",
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Glutaraldehyde cross-linked chitosan microspheres for controlled delivery of Zidovudine. / Nayak, Usha Yogendra; Gopal, Shavi; Mutalik, Srinivas; Ranjith, Averinen Kumar; Reddy, Meka Sreenivasa; Gupta, Purushotham; Udupa, Nayanabhirama.

In: Journal of Microencapsulation, Vol. 26, No. 3, 05.2009, p. 214-222.

Research output: Contribution to journalArticle

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AU - Nayak, Usha Yogendra

AU - Gopal, Shavi

AU - Mutalik, Srinivas

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AU - Reddy, Meka Sreenivasa

AU - Gupta, Purushotham

AU - Udupa, Nayanabhirama

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N2 - Zidovudine-Chitosan microspheres were prepared by a suspension cross-linking method. The chitosan was dissolved in 2 acetic acid solution and this solution was dispersed in the light liquid paraffin. Span-80 was used as an emulsifier and glutaraldehyde as cross-linking agent. The prepared microspheres were slight yellow, free flowing and characterized by drug loading, infrared spectroscopy (IR), differential scanning colorimetry (DSC) and scanning electron microscopy (SEM). The in-vitro release studies are performed in pH 7.4 buffer solution. Microspheres produced are spherical and have smooth surfaces, with sizes ranging between 60210 m, as evidenced by SEM and particle size analysis. The drug loaded microspheres showed up to 60 of entrapment and release was extended up to 1824 h. Among all the systems studied, the 35 Glutaraldehyde crosslinked, microspheres with 1 : 6 drug/chitosan ratio showed 75 release at 12 h. The infrared spectra and DSC thermograms showed stable character of zidovudine in the drug loaded microspheres and revealed the absence of drugpolymer interactions. Data obtained from in vitro release were fitted to various kinetic models and high correlation was obtained in the Higuchi model. The drug release was found to be diffusion controlled.

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