Glutathione s-transferase activity and total thiol status in chronic alcohol abusers before and 30 days after alcohol abstinence

Manjunatha S. Muttigi, Lakshmi S. Prabhu, Vivekananda Kedage, Mungli Prakash, Jeevan K. Shetty, Devaramane Virupaksha, Panambur V. Bhandary

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5 Citations (Scopus)

Abstract

Background: Glutathione S Transferase (GST) has been involved in detoxification process in the liver and its activity has been shown to be increased in alcohol abusers. In the current work we measured the GST activity, total thiol status, AST, ALT, and direct bilirubin in chronic alcohol abusers before and 30 days after alcohol abstinence and lifestyle modification. Methods: Serum and urine GST activity and total thiol status were determined using spectrophotometric methods and serum transaminases were determined using clinical chemistry analyzer. Results: We found,significant increase in serum and urine GST (p<0.001), AST (p<0.001), ALT (p<0.001), and decrease in total thiol status (p<0.001) in chronic alcohol abusers. GST activity significantly decreased (p<0.001) and total thiol status were improved significantly (p<0.001) 30 days after alcohol abstinence and lifestyle modification. Conclusion: This study provides preliminary data to suggest the role of GST as prognostic indicator of alcohol abstinence with possible trend towards an improvement in liver function.

Original languageEnglish
Pages (from-to)1-5
Number of pages5
JournalOnline Journal of Health and Allied Sciences
Volume8
Issue number1
Publication statusPublished - 01-01-2009
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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    Muttigi, M. S., Prabhu, L. S., Kedage, V., Prakash, M., Shetty, J. K., Virupaksha, D., & Bhandary, P. V. (2009). Glutathione s-transferase activity and total thiol status in chronic alcohol abusers before and 30 days after alcohol abstinence. Online Journal of Health and Allied Sciences, 8(1), 1-5.