TY - JOUR
T1 - Gold nanoparticle based biosensors for rapid pathogen detection
T2 - A review
AU - Hegde, Madhu
AU - Pai, Padmini
AU - Shetty, Manasa Gangadhar
AU - Babitha, Kampa Sundara
N1 - Funding Information:
Authors thank Department of Biotechnology (DBT) BioCare Fellowship [Grant ID: BT/PR20046/BIC/101/683/2016 ], Government of India (GOI) for financial assistance; Technology Information, Forecasting and Assessment council (TIFAC)-CORE, GOI; Department of Science and Technology (DST), DBT BUILDER grant, GOI and Manipal Academy of Higher Education (MAHE), Manipal, India for the infrastructure.
Funding Information:
This work was funded by the Department of Biotechnology (DBT) (Grant ID: BT/PR20046/BIC/101/683/2016), Government of India for providing DBT BioCare Fellowship.
Publisher Copyright:
© 2022 Elsevier B.V.
PY - 2022/12
Y1 - 2022/12
N2 - The environment around us is home to a wide range of pathogens, including those that can cause life-threatening infections. As a result, rapid and early detection of pathogens is vital for mitigating health risks. While gold standard pathogen detection technologies such as culture techniques, polymerase chain reaction, and enzyme linked immunosorbent assays are still in use, nanomaterials incorporated into biosensing systems are being evaluated for on-site, point-of-care pathogen diagnosis. In this review we discussed numerous approaches of incorporating gold nanoparticles into existing biosensor types to enable efficient pathogen detection. The sensing platforms described here include nucleic acid-based biosensors, immunosensors, enzyme biosensors, fluorescence biosensors, and bacteriophage biosensors, all of which have shown improved bio diagnostic capabilities with the inclusion of gold nanoparticles. The present review summarizes the applications of gold nanoparticles in various sensing platforms. The employment of these nanobiosensors for on-site, point-of-care pathogen detection can only be accomplished once all of the issues hindering their utilization are addressed.
AB - The environment around us is home to a wide range of pathogens, including those that can cause life-threatening infections. As a result, rapid and early detection of pathogens is vital for mitigating health risks. While gold standard pathogen detection technologies such as culture techniques, polymerase chain reaction, and enzyme linked immunosorbent assays are still in use, nanomaterials incorporated into biosensing systems are being evaluated for on-site, point-of-care pathogen diagnosis. In this review we discussed numerous approaches of incorporating gold nanoparticles into existing biosensor types to enable efficient pathogen detection. The sensing platforms described here include nucleic acid-based biosensors, immunosensors, enzyme biosensors, fluorescence biosensors, and bacteriophage biosensors, all of which have shown improved bio diagnostic capabilities with the inclusion of gold nanoparticles. The present review summarizes the applications of gold nanoparticles in various sensing platforms. The employment of these nanobiosensors for on-site, point-of-care pathogen detection can only be accomplished once all of the issues hindering their utilization are addressed.
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U2 - 10.1016/j.enmm.2022.100756
DO - 10.1016/j.enmm.2022.100756
M3 - Review article
AN - SCOPUS:85142132439
VL - 18
JO - Environmental Nanotechnology, Monitoring and Management
JF - Environmental Nanotechnology, Monitoring and Management
SN - 2215-1532
M1 - 100756
ER -
