Growth promoting potential of Ficus bengalensis root extracts in immature female rats

Research output: Contribution to journalArticle

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Abstract

The growth promoting potential of alcohol and aqueous extracts of young prop roots of Ficus bengalensis Linn. (Moraceae), a medicinal plant widely used among the tribes of the western zone of Maharashtra state, India to increase height, was studied. Its growth promoting effect was evaluated in one-month-old immature female rats. Extracts were administered to young rats for 30 days. Significant (p<0.05) increase in body weight was observed in alcohol and aqueous extract treated immature female rats. Animals treated with alcohol extract showed statistically significant difference (p<0.05) in parameters such as mean food consumption, total body length and increase in alkaline phosphatase levels, a biochemical marker for bone formation. Significant results were not observed in other parameters such as feed efficiency, tail length, relative organ weight, bone density, tibial epiphyseal cartilage width and bone hydroxy proline levels. The results obtained establish the efficacy of the plant material as well as importance of chronic studies to justify the use of this plant in growth promotion.

Original languageEnglish
Pages (from-to)268-273
Number of pages6
JournalPharmaceutical Biology
Volume47
Issue number4
DOIs
Publication statusPublished - 04-2009

Fingerprint

Ficus
Alcohols
Growth
Moraceae
Growth Plate
Organ Size
Medicinal Plants
Proline
Osteogenesis
Bone Density
Alkaline Phosphatase
Tail
India
Biomarkers
Body Weight
Bone and Bones
Food

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine

Cite this

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title = "Growth promoting potential of Ficus bengalensis root extracts in immature female rats",
abstract = "The growth promoting potential of alcohol and aqueous extracts of young prop roots of Ficus bengalensis Linn. (Moraceae), a medicinal plant widely used among the tribes of the western zone of Maharashtra state, India to increase height, was studied. Its growth promoting effect was evaluated in one-month-old immature female rats. Extracts were administered to young rats for 30 days. Significant (p<0.05) increase in body weight was observed in alcohol and aqueous extract treated immature female rats. Animals treated with alcohol extract showed statistically significant difference (p<0.05) in parameters such as mean food consumption, total body length and increase in alkaline phosphatase levels, a biochemical marker for bone formation. Significant results were not observed in other parameters such as feed efficiency, tail length, relative organ weight, bone density, tibial epiphyseal cartilage width and bone hydroxy proline levels. The results obtained establish the efficacy of the plant material as well as importance of chronic studies to justify the use of this plant in growth promotion.",
author = "Nidhiya, {I. S.R.} and K.S.R. Pai and Rao, {C. Mallikarjuna}",
note = "Cited By :7 Export Date: 10 November 2017 CODEN: PHBIF Correspondence Address: Pai, K. S. R.; Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, (MAHE), Manipal-576 104, India; email: ksr.pai@manipal.edu Chemicals/CAS: alcohol, 64-17-5; alkaline phosphatase, 9001-78-9; hydroxyproline, 51-35-4, 6912-67-0 References: Broulik, P.D., Haluzik, M., Skrha, J., The influence of nitric oxide synthase inhibitor L-NAME on bones of male rats with strepto-zotocin induced diabetes (2003) Physiol Res, 52, pp. 729-739; Caminos, J.E., Gualillo, O., Lago, F., Otero, M., Blanco, M., Gallego, R., Garcia-Caballero, T., Dieguez, C., The endogenous growth hormone secretagogue (ghrelin) is synthesized and secreted by chondrocytes (2005) Endocrinology, 146, pp. 1285-1292; Chavalittumrong, P., Chivapat, S., Attawish, A., Bansiddhi, J., Phadungpat, S., Chaorai, B., Butraporn, R., Chronic toxicity study of Portulaca grandiflora (2004) J Ethnopharmacol, 90, pp. 375-380. , Hook. Ed. Brook CGD. London; Cowell, C.T., Short stature (1995) Clinical Pediatric Endocrinology, pp. 136-141. , Blackwell Science Ltd, pp; (1956) The Wealth of India: Raw Materials, pp. 24-25. , CSIR , New Delhi, Council of Scientific and Industrial Research, pp; Flores Morales, A., Stahlberg, N., Tollet-egnell, P., Lundeberg, J., Malek, R.L., Quackenbush, J., Lee, N.H., Norstedt, G., Micro array analysis of the in vivo effects of hypophysectomy and growth hormone treatment on gene expression in the rat (2001) Endocrinology, 142, pp. 3163-3176; Fukushima, N., Hanada, R., Teranishi, H., Fukue, Y., Tachibana, T., Ishikawa, H., Takeda, S., Kojima, M., Ghrelin directly regulates bone formation (2005) J Bone Miner Res, 20, pp. 790-798; Ghosh, M.N., Toxicity studies (1984) Fundamentals of Experimental Pharmacology, pp. 153-158. , Calcutta, Scientific Book Agency, pp; Greenspan FS, Hao Li C, Simpson, Evans HM (1949): Bioassay of hypophyseal growth hormone: The tibia test. Endocrinology 45: 455-463; Groesbeck, M.D., Parlow, A.F., Daughaday, W.H., Stimulation of supra normal growth in prepubertal, adult plateaued, and hypophysetomized female rats by large doses of rat growth hormone: Physiological effects and adverse consequences (1987) Endocrinology, 120, pp. 1963-1975; Gupta, S.S., Experimental studies on pituitary diabetes. Effects of Shilajit, Ficus bengalensis and anterior pituitary extract on glucose tolerance in rats (1966) Ind J Med Res, 54, pp. 354-362; Gupta, S.S., Prospects and perspectives of natural plants products in medicine (1994) Indian J Pharmacol, 26, pp. 1-12; Kokate, C.K., Phytochemical screening (1994) Practical Pharmacognosy, pp. 103-107. , New Delhi, Vallabha Prakshan, pp; Marx, W., Simpson, E., Evans, H.M., Bioassay of the growth hormone of the anterior pituitary (1942) Endocrinology, 30, pp. 1-10; Mukherjee, P.K., Saha, K., Murugesan, T., Mandal, S.C., Pal, M., Saha, B.P., Screening of anti-diarrhoeal profile of some plant extracts of a specific region of West Bengal, India (1998) J Ethnopharmacol, 60, pp. 85-89; Neuman, R.E., Logan, M.A., The determination of collagen and elastin tissue (1950) Biol Chem, 186, pp. 549-552; Prajapati, N.D., Kumar, U., (2005) Agro's dictionary of medicinal plants, p. 35. , New Delhi, Agro Publications, p; Reiter, E.O., Rosefeld, R.G., Normal and aberrant growth (2003) Williams's Textbook of Endocrinology, pp. 1003-1079. , Elsevier Science, Philadelphia: Saunders, pp; Satapathy, K.B., Brahmam, M., Some medicinal plants used by tribals of Sundargarh District, Orissa, India (1996) Ethnobiology in Human Welfare, pp. 153-158. , New Delhi, Deep Publications, pp; Singh, K.K., Prakash, A., Indigenous phytotherapy among the Gond tribe of Uttar Pradesh. India (1994) Ethnobotany, 6, pp. 37-41; Sivarajan, W., Balachandran, I., (1994) Ayurvedic drugs and their plant sources, pp. 333-334. , Delhi, Oxford and IBH Publishing, pp; Ueno, H., Yamaguchi, H., Kangauk, H., Nakazato, M., Ghrelin: A gastric peptide that regulates food intake and energy homeostasis (2005) Regulatory Peptides, 126, pp. 11-19; Upadhye, A.S., Vartak, V.D., Kumbhojkar, M.S., Ethno-medico-botanical studies in Western Maharashtra, India (1994) Ethnobotany, 6, pp. 25-31; Varier, P.S., (1996) Indian Medicinal Plants, Compendium of 500 species, Aryavaidya sala, Kottakkal, pp. 20-26. , Hyderabad, Orient longman Limited, pp; Widmaier EP, Raff H, Strang KT (2004): Endocrine control of growth. In: Vander AJ, Sherman JH, and Luciano DS, Human Physiology - The Mechanisms of Body Function. New York, McGraw-Hill Companies, pp. 366-373; Yamanouchi, K., Yada, E., Hozumi, H., Ueno, C., Nishihara, M., Analyses of hind leg skeletons in human growth hormone transgenic rats (2004) Exp Gerontol, 39, pp. 1179-1188",
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pages = "268--273",
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Growth promoting potential of Ficus bengalensis root extracts in immature female rats. / Nidhiya, I. S.R.; Pai, K.S.R.; Rao, C. Mallikarjuna.

In: Pharmaceutical Biology, Vol. 47, No. 4, 04.2009, p. 268-273.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Growth promoting potential of Ficus bengalensis root extracts in immature female rats

AU - Nidhiya, I. S.R.

AU - Pai, K.S.R.

AU - Rao, C. Mallikarjuna

N1 - Cited By :7 Export Date: 10 November 2017 CODEN: PHBIF Correspondence Address: Pai, K. S. R.; Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, (MAHE), Manipal-576 104, India; email: ksr.pai@manipal.edu Chemicals/CAS: alcohol, 64-17-5; alkaline phosphatase, 9001-78-9; hydroxyproline, 51-35-4, 6912-67-0 References: Broulik, P.D., Haluzik, M., Skrha, J., The influence of nitric oxide synthase inhibitor L-NAME on bones of male rats with strepto-zotocin induced diabetes (2003) Physiol Res, 52, pp. 729-739; Caminos, J.E., Gualillo, O., Lago, F., Otero, M., Blanco, M., Gallego, R., Garcia-Caballero, T., Dieguez, C., The endogenous growth hormone secretagogue (ghrelin) is synthesized and secreted by chondrocytes (2005) Endocrinology, 146, pp. 1285-1292; Chavalittumrong, P., Chivapat, S., Attawish, A., Bansiddhi, J., Phadungpat, S., Chaorai, B., Butraporn, R., Chronic toxicity study of Portulaca grandiflora (2004) J Ethnopharmacol, 90, pp. 375-380. , Hook. Ed. Brook CGD. London; Cowell, C.T., Short stature (1995) Clinical Pediatric Endocrinology, pp. 136-141. , Blackwell Science Ltd, pp; (1956) The Wealth of India: Raw Materials, pp. 24-25. , CSIR , New Delhi, Council of Scientific and Industrial Research, pp; Flores Morales, A., Stahlberg, N., Tollet-egnell, P., Lundeberg, J., Malek, R.L., Quackenbush, J., Lee, N.H., Norstedt, G., Micro array analysis of the in vivo effects of hypophysectomy and growth hormone treatment on gene expression in the rat (2001) Endocrinology, 142, pp. 3163-3176; Fukushima, N., Hanada, R., Teranishi, H., Fukue, Y., Tachibana, T., Ishikawa, H., Takeda, S., Kojima, M., Ghrelin directly regulates bone formation (2005) J Bone Miner Res, 20, pp. 790-798; Ghosh, M.N., Toxicity studies (1984) Fundamentals of Experimental Pharmacology, pp. 153-158. , Calcutta, Scientific Book Agency, pp; Greenspan FS, Hao Li C, Simpson, Evans HM (1949): Bioassay of hypophyseal growth hormone: The tibia test. Endocrinology 45: 455-463; Groesbeck, M.D., Parlow, A.F., Daughaday, W.H., Stimulation of supra normal growth in prepubertal, adult plateaued, and hypophysetomized female rats by large doses of rat growth hormone: Physiological effects and adverse consequences (1987) Endocrinology, 120, pp. 1963-1975; Gupta, S.S., Experimental studies on pituitary diabetes. Effects of Shilajit, Ficus bengalensis and anterior pituitary extract on glucose tolerance in rats (1966) Ind J Med Res, 54, pp. 354-362; Gupta, S.S., Prospects and perspectives of natural plants products in medicine (1994) Indian J Pharmacol, 26, pp. 1-12; Kokate, C.K., Phytochemical screening (1994) Practical Pharmacognosy, pp. 103-107. , New Delhi, Vallabha Prakshan, pp; Marx, W., Simpson, E., Evans, H.M., Bioassay of the growth hormone of the anterior pituitary (1942) Endocrinology, 30, pp. 1-10; Mukherjee, P.K., Saha, K., Murugesan, T., Mandal, S.C., Pal, M., Saha, B.P., Screening of anti-diarrhoeal profile of some plant extracts of a specific region of West Bengal, India (1998) J Ethnopharmacol, 60, pp. 85-89; Neuman, R.E., Logan, M.A., The determination of collagen and elastin tissue (1950) Biol Chem, 186, pp. 549-552; Prajapati, N.D., Kumar, U., (2005) Agro's dictionary of medicinal plants, p. 35. , New Delhi, Agro Publications, p; Reiter, E.O., Rosefeld, R.G., Normal and aberrant growth (2003) Williams's Textbook of Endocrinology, pp. 1003-1079. , Elsevier Science, Philadelphia: Saunders, pp; Satapathy, K.B., Brahmam, M., Some medicinal plants used by tribals of Sundargarh District, Orissa, India (1996) Ethnobiology in Human Welfare, pp. 153-158. , New Delhi, Deep Publications, pp; Singh, K.K., Prakash, A., Indigenous phytotherapy among the Gond tribe of Uttar Pradesh. India (1994) Ethnobotany, 6, pp. 37-41; Sivarajan, W., Balachandran, I., (1994) Ayurvedic drugs and their plant sources, pp. 333-334. , Delhi, Oxford and IBH Publishing, pp; Ueno, H., Yamaguchi, H., Kangauk, H., Nakazato, M., Ghrelin: A gastric peptide that regulates food intake and energy homeostasis (2005) Regulatory Peptides, 126, pp. 11-19; Upadhye, A.S., Vartak, V.D., Kumbhojkar, M.S., Ethno-medico-botanical studies in Western Maharashtra, India (1994) Ethnobotany, 6, pp. 25-31; Varier, P.S., (1996) Indian Medicinal Plants, Compendium of 500 species, Aryavaidya sala, Kottakkal, pp. 20-26. , Hyderabad, Orient longman Limited, pp; Widmaier EP, Raff H, Strang KT (2004): Endocrine control of growth. In: Vander AJ, Sherman JH, and Luciano DS, Human Physiology - The Mechanisms of Body Function. New York, McGraw-Hill Companies, pp. 366-373; Yamanouchi, K., Yada, E., Hozumi, H., Ueno, C., Nishihara, M., Analyses of hind leg skeletons in human growth hormone transgenic rats (2004) Exp Gerontol, 39, pp. 1179-1188

PY - 2009/4

Y1 - 2009/4

N2 - The growth promoting potential of alcohol and aqueous extracts of young prop roots of Ficus bengalensis Linn. (Moraceae), a medicinal plant widely used among the tribes of the western zone of Maharashtra state, India to increase height, was studied. Its growth promoting effect was evaluated in one-month-old immature female rats. Extracts were administered to young rats for 30 days. Significant (p<0.05) increase in body weight was observed in alcohol and aqueous extract treated immature female rats. Animals treated with alcohol extract showed statistically significant difference (p<0.05) in parameters such as mean food consumption, total body length and increase in alkaline phosphatase levels, a biochemical marker for bone formation. Significant results were not observed in other parameters such as feed efficiency, tail length, relative organ weight, bone density, tibial epiphyseal cartilage width and bone hydroxy proline levels. The results obtained establish the efficacy of the plant material as well as importance of chronic studies to justify the use of this plant in growth promotion.

AB - The growth promoting potential of alcohol and aqueous extracts of young prop roots of Ficus bengalensis Linn. (Moraceae), a medicinal plant widely used among the tribes of the western zone of Maharashtra state, India to increase height, was studied. Its growth promoting effect was evaluated in one-month-old immature female rats. Extracts were administered to young rats for 30 days. Significant (p<0.05) increase in body weight was observed in alcohol and aqueous extract treated immature female rats. Animals treated with alcohol extract showed statistically significant difference (p<0.05) in parameters such as mean food consumption, total body length and increase in alkaline phosphatase levels, a biochemical marker for bone formation. Significant results were not observed in other parameters such as feed efficiency, tail length, relative organ weight, bone density, tibial epiphyseal cartilage width and bone hydroxy proline levels. The results obtained establish the efficacy of the plant material as well as importance of chronic studies to justify the use of this plant in growth promotion.

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