Guillain-Barré syndrome: Association with Campylobacter jejuni and Mycoplasma pneumoniae infections in India

S. P. Gorthi, Lata Kapoor, Rama Chaudhry, Nidhi Sharma, Guillermo I. Perez-Perez, Pinaki Panigrahi, Madhuri Behari

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Background. Guillain-Barré syndrome is the most common cause of acute neuromuscular paralysis and is considered a post-infectious disease. Methods. Twenty patients with Guillain-Barré syndrome admitted to the Neurosciences Centre at the All India Institute of Medical Sciences from November 1997 to August 1998 were investigated for evidence of antecedent infections. This case-control study included 2 controls for each patient, one a household control and the other an age- and sex-matched hospital control suffering from a neurological illness other than Guillain-Barré syndrome. Evidence of recent Campylobacter jejuni infection was investigated by culture and serology, and for Mycoplasma pneumoniae by serology. Results. There was evidence of recent C. jejuni infection in 35% of the patients compared with 25% of household controls and none of the hospital controls. M. pneumoniae infection was seen in 50% of patients compared with 25% of household controls and 15% of hospital controls. About one-third of the patients (30%) had evidence of both infections. The association of both infections in patients was found to be statistically significant as compared to hospital controls. Conclusion. C. jejuni and M. pneumoniae may be important antecedent illnesses in patients with Guillain-Barré syndrome in India.

Original languageEnglish
Pages (from-to)137-139
Number of pages3
JournalNational Medical Journal of India
Volume19
Issue number3
Publication statusPublished - 01-05-2006

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Mycoplasma pneumoniae
Campylobacter jejuni
India
Infection
Campylobacter Infections
Serology
Neurosciences
Paralysis
Communicable Diseases
Case-Control Studies

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Gorthi, S. P., Kapoor, L., Chaudhry, R., Sharma, N., Perez-Perez, G. I., Panigrahi, P., & Behari, M. (2006). Guillain-Barré syndrome: Association with Campylobacter jejuni and Mycoplasma pneumoniae infections in India. National Medical Journal of India, 19(3), 137-139.
Gorthi, S. P. ; Kapoor, Lata ; Chaudhry, Rama ; Sharma, Nidhi ; Perez-Perez, Guillermo I. ; Panigrahi, Pinaki ; Behari, Madhuri. / Guillain-Barré syndrome : Association with Campylobacter jejuni and Mycoplasma pneumoniae infections in India. In: National Medical Journal of India. 2006 ; Vol. 19, No. 3. pp. 137-139.
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abstract = "Background. Guillain-Barr{\'e} syndrome is the most common cause of acute neuromuscular paralysis and is considered a post-infectious disease. Methods. Twenty patients with Guillain-Barr{\'e} syndrome admitted to the Neurosciences Centre at the All India Institute of Medical Sciences from November 1997 to August 1998 were investigated for evidence of antecedent infections. This case-control study included 2 controls for each patient, one a household control and the other an age- and sex-matched hospital control suffering from a neurological illness other than Guillain-Barr{\'e} syndrome. Evidence of recent Campylobacter jejuni infection was investigated by culture and serology, and for Mycoplasma pneumoniae by serology. Results. There was evidence of recent C. jejuni infection in 35{\%} of the patients compared with 25{\%} of household controls and none of the hospital controls. M. pneumoniae infection was seen in 50{\%} of patients compared with 25{\%} of household controls and 15{\%} of hospital controls. About one-third of the patients (30{\%}) had evidence of both infections. The association of both infections in patients was found to be statistically significant as compared to hospital controls. Conclusion. C. jejuni and M. pneumoniae may be important antecedent illnesses in patients with Guillain-Barr{\'e} syndrome in India.",
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Gorthi, SP, Kapoor, L, Chaudhry, R, Sharma, N, Perez-Perez, GI, Panigrahi, P & Behari, M 2006, 'Guillain-Barré syndrome: Association with Campylobacter jejuni and Mycoplasma pneumoniae infections in India', National Medical Journal of India, vol. 19, no. 3, pp. 137-139.

Guillain-Barré syndrome : Association with Campylobacter jejuni and Mycoplasma pneumoniae infections in India. / Gorthi, S. P.; Kapoor, Lata; Chaudhry, Rama; Sharma, Nidhi; Perez-Perez, Guillermo I.; Panigrahi, Pinaki; Behari, Madhuri.

In: National Medical Journal of India, Vol. 19, No. 3, 01.05.2006, p. 137-139.

Research output: Contribution to journalArticle

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T1 - Guillain-Barré syndrome

T2 - Association with Campylobacter jejuni and Mycoplasma pneumoniae infections in India

AU - Gorthi, S. P.

AU - Kapoor, Lata

AU - Chaudhry, Rama

AU - Sharma, Nidhi

AU - Perez-Perez, Guillermo I.

AU - Panigrahi, Pinaki

AU - Behari, Madhuri

PY - 2006/5/1

Y1 - 2006/5/1

N2 - Background. Guillain-Barré syndrome is the most common cause of acute neuromuscular paralysis and is considered a post-infectious disease. Methods. Twenty patients with Guillain-Barré syndrome admitted to the Neurosciences Centre at the All India Institute of Medical Sciences from November 1997 to August 1998 were investigated for evidence of antecedent infections. This case-control study included 2 controls for each patient, one a household control and the other an age- and sex-matched hospital control suffering from a neurological illness other than Guillain-Barré syndrome. Evidence of recent Campylobacter jejuni infection was investigated by culture and serology, and for Mycoplasma pneumoniae by serology. Results. There was evidence of recent C. jejuni infection in 35% of the patients compared with 25% of household controls and none of the hospital controls. M. pneumoniae infection was seen in 50% of patients compared with 25% of household controls and 15% of hospital controls. About one-third of the patients (30%) had evidence of both infections. The association of both infections in patients was found to be statistically significant as compared to hospital controls. Conclusion. C. jejuni and M. pneumoniae may be important antecedent illnesses in patients with Guillain-Barré syndrome in India.

AB - Background. Guillain-Barré syndrome is the most common cause of acute neuromuscular paralysis and is considered a post-infectious disease. Methods. Twenty patients with Guillain-Barré syndrome admitted to the Neurosciences Centre at the All India Institute of Medical Sciences from November 1997 to August 1998 were investigated for evidence of antecedent infections. This case-control study included 2 controls for each patient, one a household control and the other an age- and sex-matched hospital control suffering from a neurological illness other than Guillain-Barré syndrome. Evidence of recent Campylobacter jejuni infection was investigated by culture and serology, and for Mycoplasma pneumoniae by serology. Results. There was evidence of recent C. jejuni infection in 35% of the patients compared with 25% of household controls and none of the hospital controls. M. pneumoniae infection was seen in 50% of patients compared with 25% of household controls and 15% of hospital controls. About one-third of the patients (30%) had evidence of both infections. The association of both infections in patients was found to be statistically significant as compared to hospital controls. Conclusion. C. jejuni and M. pneumoniae may be important antecedent illnesses in patients with Guillain-Barré syndrome in India.

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