Haemophagocytic lymphohistiocytosis in patients with human immunodeficiency virus infection: To treat or not to treat

Farhan Fazal, Nitin Gupta, Shivabalan Kathavarayan Ramu, Aditya Nayan, Naval Kishore Vikram, Animesh Ray

Research output: Contribution to journalArticlepeer-review

Abstract

Haemophagocytic lymphohistiocytosis (HLH) in Human Immunodeficiency Virus (HIV) infected individuals can either be due to the disease itself or due to associated infections/malignancies. The treatment for HLH requires immunosuppressive therapy but administering immunosuppressive therapy to an already immunosuppressed patient (HIV infection) is complex. We present two such cases of HLH in patients infected with HIV. In the first case, no alternate cause for HLH was found even after extensive investigations and it was attributed to the uncontrolled HIV replication. Patient was started on dexamethasone for the same but succumbed to hospital acquired pneumonia. The second patient was diagnosed with Hodgkin's lymphoma but he succumbed to his illness before initiating immunosuppressive therapy for HLH. We report these cases to highlight the dilemma and a need for further research in this direction

Original languageEnglish
Article number105
JournalPan African Medical Journal
Volume32
DOIs
Publication statusPublished - 01-01-2019

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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