Health technology assessment in the era of personalized health care

Lidia Becla, Jeantine E. Lunshof, David Gurwitz, Tobias Schulte In Den Bäumen, Hans V. Westerhoff, Bodo M H Lange, Angela Brand

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Objectives: This article examines the challenges for health technology assessment (HTA) in the light of new developments of personalized health care, focusing on European HTA perspectives. Methods: Using the example of the Integrated Genome Research Network - Mutanom (IG Mutanom) project, with focus on personalized cancer diagnostics and treatment, we assess the scope of current HTA and examine it prospectively in the context of the translation of basic and clinical research into public health genomics and personalized health care. Results: The approaches developed within the IG-Mutanom project are based on innovative technology potentially providing targeted therapies for cancer; making translation into clinical practice requires a novel course of action, however. New models of HTA are needed that can account for the unique types of evidence inherent to individualized targeted therapies. Using constructive health technology assessment (CTA) models is an option, but further suitable models should be developed. Conclusions: Integrative, systems biology-based approaches toward personalized medicine call for novel assessment methods. The translation of their highly innovative technologies into the practice of health care requires the development of new HTA concepts.

Original languageEnglish
Pages (from-to)118-126
Number of pages9
JournalInternational Journal of Technology Assessment in Health Care
Volume27
Issue number2
DOIs
Publication statusPublished - 04-2011

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Biomedical Technology Assessment
Delivery of Health Care
Technology
Precision Medicine
Systems Biology
Genomics
Research
Neoplasms
Therapeutics
Public Health
Genome

All Science Journal Classification (ASJC) codes

  • Health Policy

Cite this

Becla, L., Lunshof, J. E., Gurwitz, D., Schulte In Den Bäumen, T., Westerhoff, H. V., Lange, B. M. H., & Brand, A. (2011). Health technology assessment in the era of personalized health care. International Journal of Technology Assessment in Health Care, 27(2), 118-126. https://doi.org/10.1017/S026646231100002X
Becla, Lidia ; Lunshof, Jeantine E. ; Gurwitz, David ; Schulte In Den Bäumen, Tobias ; Westerhoff, Hans V. ; Lange, Bodo M H ; Brand, Angela. / Health technology assessment in the era of personalized health care. In: International Journal of Technology Assessment in Health Care. 2011 ; Vol. 27, No. 2. pp. 118-126.
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Becla, L, Lunshof, JE, Gurwitz, D, Schulte In Den Bäumen, T, Westerhoff, HV, Lange, BMH & Brand, A 2011, 'Health technology assessment in the era of personalized health care', International Journal of Technology Assessment in Health Care, vol. 27, no. 2, pp. 118-126. https://doi.org/10.1017/S026646231100002X

Health technology assessment in the era of personalized health care. / Becla, Lidia; Lunshof, Jeantine E.; Gurwitz, David; Schulte In Den Bäumen, Tobias; Westerhoff, Hans V.; Lange, Bodo M H; Brand, Angela.

In: International Journal of Technology Assessment in Health Care, Vol. 27, No. 2, 04.2011, p. 118-126.

Research output: Contribution to journalArticle

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Becla L, Lunshof JE, Gurwitz D, Schulte In Den Bäumen T, Westerhoff HV, Lange BMH et al. Health technology assessment in the era of personalized health care. International Journal of Technology Assessment in Health Care. 2011 Apr;27(2):118-126. https://doi.org/10.1017/S026646231100002X