Hemagglutination Inhibition Antibody Response Following Influenza A(H1N1)pdm09 Virus Natural Infection: A Cross-Sectional Study from Thirthahalli, Karnataka, India

Chandana Sai Hari Alladi, Anitha Jagadesh, Suresha G. Prabhu, Govindakarnavar Arunkumar

Research output: Contribution to journalArticle

Abstract

Influenza viruses are major respiratory pathogens that cause seasonal epidemics and occasional pandemics. Immune response to influenza viruses is majorly targeted against the hemagglutinin antigen. A laboratory-based retrospective cross-sectional study was conducted on 50 acute and 50 follow-up samples to assess the immune response to influenza A(H1N1)pdm09 virus after natural infection and detect the presence of pre-existing antibodies against influenza A(H3N2) and influenza B viruses. Two-fourfold rise in hemagglutination-inhibition (HAI) titer was observed in 100% of the follow-up samples for influenza A(H1N1)pdm09 virus. No change in HAI titers for influenza A(H3N2) and influenza B viruses was observed.

Original languageEnglish
Pages (from-to)230-233
Number of pages4
JournalViral Immunology
Volume32
Issue number5
DOIs
Publication statusPublished - 01-06-2019

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H1N1 Subtype Influenza A Virus
Hemagglutination
Virus Diseases
Human Influenza
Antibody Formation
India
Cross-Sectional Studies
Influenza B virus
Orthomyxoviridae
Hemagglutinins
Pandemics
Antigens
Antibodies
Infection

All Science Journal Classification (ASJC) codes

  • Immunology
  • Molecular Medicine
  • Virology

Cite this

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abstract = "Influenza viruses are major respiratory pathogens that cause seasonal epidemics and occasional pandemics. Immune response to influenza viruses is majorly targeted against the hemagglutinin antigen. A laboratory-based retrospective cross-sectional study was conducted on 50 acute and 50 follow-up samples to assess the immune response to influenza A(H1N1)pdm09 virus after natural infection and detect the presence of pre-existing antibodies against influenza A(H3N2) and influenza B viruses. Two-fourfold rise in hemagglutination-inhibition (HAI) titer was observed in 100{\%} of the follow-up samples for influenza A(H1N1)pdm09 virus. No change in HAI titers for influenza A(H3N2) and influenza B viruses was observed.",
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Hemagglutination Inhibition Antibody Response Following Influenza A(H1N1)pdm09 Virus Natural Infection : A Cross-Sectional Study from Thirthahalli, Karnataka, India. / Alladi, Chandana Sai Hari; Jagadesh, Anitha; Prabhu, Suresha G.; Arunkumar, Govindakarnavar.

In: Viral Immunology, Vol. 32, No. 5, 01.06.2019, p. 230-233.

Research output: Contribution to journalArticle

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