Hemoglobin, Vitamin D, and lipids in subclinical hypothyroid patients - Do the anti -thyroid autoantibodies titer matters?

T. Jaseem, Anupama Hegde, M. Chakrapani, Sathish Rao

Research output: Contribution to journalArticle

Abstract

Hashimoto's thyroiditis, the commonest cause of hypothyroidism has been proposed as a risk factor for atherosclerosis independent of thyroid function. The aim of this study was to investigate whether Hashimoto's thyroiditis validated by their anti-TPO positivity have any effect on hyperlipidemia, Hemoglobin, Vitamin D independent of thyroid function in newly diagnosed subclinical hypothyroid patients (SCH) subjects with TSH ≤ 10μIU/ml. 40 newly diagnosed SCH and 40 healthy euthyroid controls were included in this study. Based on anti-TPO status, the SCH subjects was divided into TPO positive and negative groups. Serum lipid, hemoglobin and Vitamin D levels were determined and compared between among the TPO positive and negative SCH subjects. Subjects with and without anti-TPO had significant differences in levels of low-density lipoprotein, total cholesterol, and nonHDL cholesterol. In correlation analysis, anti-TPO showed statistically significant association with Hb, LDL and Vitamin D. Subclinical hypothyroidism with thyroid autoimmunity is associated with a marginal decrease in hemoglobin and elevation in LDL. Whether this holds, any bearing on promoting cardiovascular risk needs to be considered further.

Original languageEnglish
Pages (from-to)1175-1180
Number of pages6
JournalBiomedical and Pharmacology Journal
Volume10
Issue number3
DOIs
Publication statusPublished - 01-01-2017

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Vitamin D
Autoantibodies
Thyroid Gland
Lipids
Hashimoto Disease
Hypothyroidism
Hyperlipidemias
Autoimmunity
LDL Cholesterol
Atherosclerosis
Hemoglobins
Cholesterol
hemoglobin D
Serum

All Science Journal Classification (ASJC) codes

  • Pharmacology

Cite this

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abstract = "Hashimoto's thyroiditis, the commonest cause of hypothyroidism has been proposed as a risk factor for atherosclerosis independent of thyroid function. The aim of this study was to investigate whether Hashimoto's thyroiditis validated by their anti-TPO positivity have any effect on hyperlipidemia, Hemoglobin, Vitamin D independent of thyroid function in newly diagnosed subclinical hypothyroid patients (SCH) subjects with TSH ≤ 10μIU/ml. 40 newly diagnosed SCH and 40 healthy euthyroid controls were included in this study. Based on anti-TPO status, the SCH subjects was divided into TPO positive and negative groups. Serum lipid, hemoglobin and Vitamin D levels were determined and compared between among the TPO positive and negative SCH subjects. Subjects with and without anti-TPO had significant differences in levels of low-density lipoprotein, total cholesterol, and nonHDL cholesterol. In correlation analysis, anti-TPO showed statistically significant association with Hb, LDL and Vitamin D. Subclinical hypothyroidism with thyroid autoimmunity is associated with a marginal decrease in hemoglobin and elevation in LDL. Whether this holds, any bearing on promoting cardiovascular risk needs to be considered further.",
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Hemoglobin, Vitamin D, and lipids in subclinical hypothyroid patients - Do the anti -thyroid autoantibodies titer matters? / Jaseem, T.; Hegde, Anupama; Chakrapani, M.; Rao, Sathish.

In: Biomedical and Pharmacology Journal, Vol. 10, No. 3, 01.01.2017, p. 1175-1180.

Research output: Contribution to journalArticle

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