Hemophagocytic lymphohistiocytosis in a 19 year old critically Ill patient

Desai Nayan, S. Bhagyalakshmi, Karnik Nitin, Jijina Farah, S. Chandrakala

Research output: Contribution to journalArticle

Abstract

Haemophagocytic lymphohistiocytosis (HLH) describes a clinical syndrome of hyperinflammation resulting in an uncontrolled and ineffective immune response. It presents with a clinical picture of likely sepsis, i.e., fever, laboratory evidence of inflammatory response, coagulopathy and thrombocytopaenia should be appropriately investigated and managed for sepsis, but the possible diagnosis of HLH should be borne in mind. Awareness of the clinical symptoms and of diagnostic criteria for HLH is crucial to starting immunosuppressive/ immunomodulatory and cytotoxic drugs in time. We present a case of HLH in a 19 year old male who presented with fever, neurological symptoms, cytopaenias, laboratory markers of inflammation and bone marrow aspirate showed hemophagocytosis.

Original languageEnglish
Pages (from-to)117-120
Number of pages4
JournalIndian Journal of Hematology and Blood Transfusion
Volume28
Issue number2
DOIs
Publication statusPublished - 01-06-2012

Fingerprint

Hemophagocytic Lymphohistiocytosis
Critical Illness
Sepsis
Fever
Immunosuppressive Agents
Biomarkers
Bone Marrow
Inflammation
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Hematology

Cite this

Nayan, Desai ; Bhagyalakshmi, S. ; Nitin, Karnik ; Farah, Jijina ; Chandrakala, S. / Hemophagocytic lymphohistiocytosis in a 19 year old critically Ill patient. In: Indian Journal of Hematology and Blood Transfusion. 2012 ; Vol. 28, No. 2. pp. 117-120.
@article{a3928e9fc77b44b0bd2670a1adda1fd3,
title = "Hemophagocytic lymphohistiocytosis in a 19 year old critically Ill patient",
abstract = "Haemophagocytic lymphohistiocytosis (HLH) describes a clinical syndrome of hyperinflammation resulting in an uncontrolled and ineffective immune response. It presents with a clinical picture of likely sepsis, i.e., fever, laboratory evidence of inflammatory response, coagulopathy and thrombocytopaenia should be appropriately investigated and managed for sepsis, but the possible diagnosis of HLH should be borne in mind. Awareness of the clinical symptoms and of diagnostic criteria for HLH is crucial to starting immunosuppressive/ immunomodulatory and cytotoxic drugs in time. We present a case of HLH in a 19 year old male who presented with fever, neurological symptoms, cytopaenias, laboratory markers of inflammation and bone marrow aspirate showed hemophagocytosis.",
author = "Desai Nayan and S. Bhagyalakshmi and Karnik Nitin and Jijina Farah and S. Chandrakala",
year = "2012",
month = "6",
day = "1",
doi = "10.1007/s12288-011-0104-0",
language = "English",
volume = "28",
pages = "117--120",
journal = "Indian Journal of Hematology and Blood Transfusion",
issn = "0971-4502",
publisher = "Springer India",
number = "2",

}

Hemophagocytic lymphohistiocytosis in a 19 year old critically Ill patient. / Nayan, Desai; Bhagyalakshmi, S.; Nitin, Karnik; Farah, Jijina; Chandrakala, S.

In: Indian Journal of Hematology and Blood Transfusion, Vol. 28, No. 2, 01.06.2012, p. 117-120.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Hemophagocytic lymphohistiocytosis in a 19 year old critically Ill patient

AU - Nayan, Desai

AU - Bhagyalakshmi, S.

AU - Nitin, Karnik

AU - Farah, Jijina

AU - Chandrakala, S.

PY - 2012/6/1

Y1 - 2012/6/1

N2 - Haemophagocytic lymphohistiocytosis (HLH) describes a clinical syndrome of hyperinflammation resulting in an uncontrolled and ineffective immune response. It presents with a clinical picture of likely sepsis, i.e., fever, laboratory evidence of inflammatory response, coagulopathy and thrombocytopaenia should be appropriately investigated and managed for sepsis, but the possible diagnosis of HLH should be borne in mind. Awareness of the clinical symptoms and of diagnostic criteria for HLH is crucial to starting immunosuppressive/ immunomodulatory and cytotoxic drugs in time. We present a case of HLH in a 19 year old male who presented with fever, neurological symptoms, cytopaenias, laboratory markers of inflammation and bone marrow aspirate showed hemophagocytosis.

AB - Haemophagocytic lymphohistiocytosis (HLH) describes a clinical syndrome of hyperinflammation resulting in an uncontrolled and ineffective immune response. It presents with a clinical picture of likely sepsis, i.e., fever, laboratory evidence of inflammatory response, coagulopathy and thrombocytopaenia should be appropriately investigated and managed for sepsis, but the possible diagnosis of HLH should be borne in mind. Awareness of the clinical symptoms and of diagnostic criteria for HLH is crucial to starting immunosuppressive/ immunomodulatory and cytotoxic drugs in time. We present a case of HLH in a 19 year old male who presented with fever, neurological symptoms, cytopaenias, laboratory markers of inflammation and bone marrow aspirate showed hemophagocytosis.

UR - http://www.scopus.com/inward/record.url?scp=84861456371&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84861456371&partnerID=8YFLogxK

U2 - 10.1007/s12288-011-0104-0

DO - 10.1007/s12288-011-0104-0

M3 - Article

VL - 28

SP - 117

EP - 120

JO - Indian Journal of Hematology and Blood Transfusion

JF - Indian Journal of Hematology and Blood Transfusion

SN - 0971-4502

IS - 2

ER -