Hemosiderin tubulopathy-induced acute kidney injury - A rare initial manifestation of paroxysmal nocturnal hemoglobinuria

Srikanth Prasad Rao, Sindhura Lakshmi Koulmane Laxminarayana, Shankar Prasad Nagaraju, Mahesha Vankalakunti, Ravindra Prabhu Attur, Chethan Manohar

Research output: Contribution to journalArticlepeer-review

Abstract

Paroxysmal nocturnal hemoglobinuria (PNH) is characterized by episodes of intravascular hemolysis, infections, and thromboembolic complications. Renal abnormalities are rare which occur either due to hemolytic crisis or repeated thrombotic episodes involving small venules. Acute kidney injury (AKI) requiring hemodialysis due to toxic effects of hemoglobinuria, with a stable disease is exceptional. We describe a case of an elderly gentleman presenting with features of severe AKI requiring hemodialysis due to hemosiderin tubulotoxicity as the first manifestation of PNH. The diagnosis was challenging because of the rarity and unfamiliarity with this entity. The outcome was complete recovery of renal function with hemodialysis.

Original languageEnglish
Pages (from-to)1232-1236
Number of pages5
JournalSaudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia
Volume29
Issue number5
DOIs
Publication statusPublished - 01-09-2018

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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