Hepatic Encephalopathy in Malaria or Artesunate Toxicity

A Dilemma in Diagnosis

K. G. Gopakumar, Kiran Baliga, Murali Keshav, Santharam Baliga

Research output: Contribution to journalArticle

Abstract

Malaria remains an overwhelming problem with around 214 million cases reported worldwide each year. It remains a major health problem in the tropical developing countries and India accounts for 70% of the total malaria incidence in the Southeast Asia region. Even though, artesunate, a novel drug used in the treatment of chloroquine-resistant cases of Plasmodium falciparum infection causes transient transaminitis (elevation of alanine and aspartate transaminases), hepatitis and hepatic encephalopathy are very rare. We encountered a child with falciparum malaria, who accidently ingested artesunate tablets (16 mg/kg) and developed hepatic encephalopathy with clinical and biochemical improvement in a matter of 4 to 5 days. There are only a few reports of children with malaria developing hepatic encephalopathy, with or without coinfection with hepatotropic viruses. Also, there are no reports of hepatic encephalopathy secondary to artesunate overdose, creating a dilemma in diagnosis and management.

Original languageEnglish
Pages (from-to)75-77
Number of pages3
JournalJournal of Pediatric Infectious Diseases
Volume13
Issue number1
DOIs
Publication statusPublished - 01-03-2018

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Hepatic Encephalopathy
Malaria
Southeastern Asia
Falciparum Malaria
Chloroquine
Plasmodium falciparum
Aspartate Aminotransferases
Alanine Transaminase
Coinfection
Hepatitis
Developing Countries
Tablets
India
Viruses
artesunate
Incidence
Health
Pharmaceutical Preparations
Therapeutics

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Infectious Diseases

Cite this

Gopakumar, K. G. ; Baliga, Kiran ; Keshav, Murali ; Baliga, Santharam. / Hepatic Encephalopathy in Malaria or Artesunate Toxicity : A Dilemma in Diagnosis. In: Journal of Pediatric Infectious Diseases. 2018 ; Vol. 13, No. 1. pp. 75-77.
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Hepatic Encephalopathy in Malaria or Artesunate Toxicity : A Dilemma in Diagnosis. / Gopakumar, K. G.; Baliga, Kiran; Keshav, Murali; Baliga, Santharam.

In: Journal of Pediatric Infectious Diseases, Vol. 13, No. 1, 01.03.2018, p. 75-77.

Research output: Contribution to journalArticle

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