Hepatoid variant of yolk sac tumor of both ovaries with widespread intra-abdominal and lung metastasis

A case report

Srilatha Parampalli Srinivas, Archana Shivamurthy, Lakshmi Rao, Rajeshwari Gurumoorthy Bhat

Research output: Contribution to journalArticle

Abstract

Hepatoid variant of yolk sac tumor of ovary is an unusual tumor with an aggressive behavior. It is usually observed in young females, presents with abdominal complaints and is associated with raised α-fetoprotein (AFP) levels. It should be differentiated from other hepatoid tumors involving the ovary. A complete patient evaluation with gross, microscopy, and immunohistochemistry can identify the site of origin to administer appropriate treatment. The current study reported the case of a 30-year-old married parous female presenting with abdominal distention and pain of two months duration. She had regular menstrual cycles. Based on lab investigations her serum AFP level was markedly raised to 34,244 ng/mL (normal range: 0-9 ng/mL). Computerized tomography (CT) scan showed large lobulated heterogeneous mass in both ovaries and omental, gall bladder, and lung metastasis. A CT guided biopsy of the ovarian mass was done. On histopathology, a differential diagnosis of hepatoid variant of yolk sac tumor, hepatoid carcinoma of ovary and hepatoid tumor arising from gall bladder metastasizing to the ovary were observed. Patient underwent surgery. Per operatively gross ascites with bilateral ovarian mass, extensive omental, pelvic, and gall bladder deposits were observed. Bilateral salpingo-oophorectomy with omental deposit biopsy was conducted. Histopathology along with immunohistochemistry confirmed a diagnosis of hepatoid variant of yolk sac tumor in both ovaries with widespread intra-abdominal metastasis.

Original languageEnglish
Pages (from-to)289-293
Number of pages5
JournalIranian Journal of Pathology
Volume13
Issue number2
Publication statusPublished - 01-03-2018

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Endodermal Sinus Tumor
Ovary
Neoplasm Metastasis
Lung
Urinary Bladder
Immunohistochemistry
Tomography
Fetal Proteins
Biopsy
Neoplasms
Ovariectomy
Menstrual Cycle
Ascites
Abdominal Pain
Microscopy
Reference Values
Differential Diagnosis
Carcinoma
Serum

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

Cite this

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title = "Hepatoid variant of yolk sac tumor of both ovaries with widespread intra-abdominal and lung metastasis: A case report",
abstract = "Hepatoid variant of yolk sac tumor of ovary is an unusual tumor with an aggressive behavior. It is usually observed in young females, presents with abdominal complaints and is associated with raised α-fetoprotein (AFP) levels. It should be differentiated from other hepatoid tumors involving the ovary. A complete patient evaluation with gross, microscopy, and immunohistochemistry can identify the site of origin to administer appropriate treatment. The current study reported the case of a 30-year-old married parous female presenting with abdominal distention and pain of two months duration. She had regular menstrual cycles. Based on lab investigations her serum AFP level was markedly raised to 34,244 ng/mL (normal range: 0-9 ng/mL). Computerized tomography (CT) scan showed large lobulated heterogeneous mass in both ovaries and omental, gall bladder, and lung metastasis. A CT guided biopsy of the ovarian mass was done. On histopathology, a differential diagnosis of hepatoid variant of yolk sac tumor, hepatoid carcinoma of ovary and hepatoid tumor arising from gall bladder metastasizing to the ovary were observed. Patient underwent surgery. Per operatively gross ascites with bilateral ovarian mass, extensive omental, pelvic, and gall bladder deposits were observed. Bilateral salpingo-oophorectomy with omental deposit biopsy was conducted. Histopathology along with immunohistochemistry confirmed a diagnosis of hepatoid variant of yolk sac tumor in both ovaries with widespread intra-abdominal metastasis.",
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Hepatoid variant of yolk sac tumor of both ovaries with widespread intra-abdominal and lung metastasis : A case report. / Srinivas, Srilatha Parampalli; Shivamurthy, Archana; Rao, Lakshmi; Bhat, Rajeshwari Gurumoorthy.

In: Iranian Journal of Pathology, Vol. 13, No. 2, 01.03.2018, p. 289-293.

Research output: Contribution to journalArticle

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