Hepatoprotective activity of combination of Phyllanthus niruri and Curcuma longa extracts against ethanol induced toxicity in wistar rats

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Abstract

Alcohol is an important substance with addictive potential. Alcohol is metabolised in the liver. Free radicals generated during the metabolism of alcohol is responsible for hepatic damage. Options available for treatment of alcohol induced liver disease was inadequate in modern medicine. Phyllanthus niruri and Curcuma longa have been shown to have hepatoprotective activity. Hence this study was undertaken to evaluate the effects of Phyllanthus niruri and Curcuma longa in combination to prevent alcohol induced hepatotoxicity. Evaluation was done by comapring the levels of liver enzymes, bilirubin, antioxidants, thiopentone induced sleeping time and liver hisotpathology in various groups of albino rats after administration of ethanol. Treatment with extracts of Phyllanthus niruri and Curcuma longa caused a significant reduction in liver enzymes, bilirubin levels and increase in antioxidants. The results of our study indicate that combination of Phyllanthus niruri and Curcuma longa possess significant hepatoprotective activity against alcohol induced liver damage.

Original languageEnglish
Pages (from-to)P12-P18
JournalInternational Journal of Pharma and Bio Sciences
Volume7
Issue number1
Publication statusPublished - 01-01-2016

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Phyllanthus
Curcuma
Liver
Toxicity
Wistar Rats
Rats
Ethanol
Alcohols
Bilirubin
Antioxidants
Modern 1601-history
Thiopental
Enzymes
Metabolism
Medicine
Free Radicals
Liver Diseases

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

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title = "Hepatoprotective activity of combination of Phyllanthus niruri and Curcuma longa extracts against ethanol induced toxicity in wistar rats",
abstract = "Alcohol is an important substance with addictive potential. Alcohol is metabolised in the liver. Free radicals generated during the metabolism of alcohol is responsible for hepatic damage. Options available for treatment of alcohol induced liver disease was inadequate in modern medicine. Phyllanthus niruri and Curcuma longa have been shown to have hepatoprotective activity. Hence this study was undertaken to evaluate the effects of Phyllanthus niruri and Curcuma longa in combination to prevent alcohol induced hepatotoxicity. Evaluation was done by comapring the levels of liver enzymes, bilirubin, antioxidants, thiopentone induced sleeping time and liver hisotpathology in various groups of albino rats after administration of ethanol. Treatment with extracts of Phyllanthus niruri and Curcuma longa caused a significant reduction in liver enzymes, bilirubin levels and increase in antioxidants. The results of our study indicate that combination of Phyllanthus niruri and Curcuma longa possess significant hepatoprotective activity against alcohol induced liver damage.",
author = "Vinay, {B. S.} and Shalini Adiga and Shobha Kamath and {Mohandas Rao}, {K. G.} and S. Avin",
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T1 - Hepatoprotective activity of combination of Phyllanthus niruri and Curcuma longa extracts against ethanol induced toxicity in wistar rats

AU - Vinay, B. S.

AU - Adiga, Shalini

AU - Kamath, Shobha

AU - Mohandas Rao, K. G.

AU - Avin, S.

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Alcohol is an important substance with addictive potential. Alcohol is metabolised in the liver. Free radicals generated during the metabolism of alcohol is responsible for hepatic damage. Options available for treatment of alcohol induced liver disease was inadequate in modern medicine. Phyllanthus niruri and Curcuma longa have been shown to have hepatoprotective activity. Hence this study was undertaken to evaluate the effects of Phyllanthus niruri and Curcuma longa in combination to prevent alcohol induced hepatotoxicity. Evaluation was done by comapring the levels of liver enzymes, bilirubin, antioxidants, thiopentone induced sleeping time and liver hisotpathology in various groups of albino rats after administration of ethanol. Treatment with extracts of Phyllanthus niruri and Curcuma longa caused a significant reduction in liver enzymes, bilirubin levels and increase in antioxidants. The results of our study indicate that combination of Phyllanthus niruri and Curcuma longa possess significant hepatoprotective activity against alcohol induced liver damage.

AB - Alcohol is an important substance with addictive potential. Alcohol is metabolised in the liver. Free radicals generated during the metabolism of alcohol is responsible for hepatic damage. Options available for treatment of alcohol induced liver disease was inadequate in modern medicine. Phyllanthus niruri and Curcuma longa have been shown to have hepatoprotective activity. Hence this study was undertaken to evaluate the effects of Phyllanthus niruri and Curcuma longa in combination to prevent alcohol induced hepatotoxicity. Evaluation was done by comapring the levels of liver enzymes, bilirubin, antioxidants, thiopentone induced sleeping time and liver hisotpathology in various groups of albino rats after administration of ethanol. Treatment with extracts of Phyllanthus niruri and Curcuma longa caused a significant reduction in liver enzymes, bilirubin levels and increase in antioxidants. The results of our study indicate that combination of Phyllanthus niruri and Curcuma longa possess significant hepatoprotective activity against alcohol induced liver damage.

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