Hepatoprotective activity of Nelumbo nucifera Geartn. Flower: An ethnopharmacological study

G.M.M. Rao, P. Pushpangadan, A. Shirwaikar

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Nelumbo nucifera Geartn. (Nymphaeaceae), a medicinal plant mentioned in Ayurveda for the treatment of liver disorders, has not been subjected to systematic scientific investigations to assess its hepatoprotective effects. The present study was therefore, undertaken to investigate the hepatoprotective activity of this plant. 50% aqueous ethanolic extract of flowers of Nelumbo nucifera Geartn. (Nymphaeaceae) showed a significant dose dependent (200 mg, 400 mg/kg p.o. × 10) protective effect against carbon tetrachloride and paracetamol induced hepatotoxicity in Sprague-Dawley rats. The degree of protection was measured using biochemical parameters like serum aspartate aminotransferase (AST), serum alanine aminotransferase (ALT), serum alkaline phosphatase (SAKP) and serum bilirubin (SB). Liver sections were also studied histopathologically to confirm the biochemical results. The results indicated that the 400 mg/kg p.o. of 50% aqueous ethanolic extract of flowers of Nelumbo nucifera Geartn. exhibited the most significant (P
Original languageEnglish
Pages (from-to)79-88
Number of pages10
JournalActa Pharmaceutica Turcica
Volume47
Issue number1
Publication statusPublished - 2005
Externally publishedYes

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