Hepatoprotective activity of Phyllanthusniruri in thioacetamide induced hepatotoxicity in male wistar rats

V. R. Manohar, M. R.S.M. Pai, P. Sabitha, Paipushpalatha, Rai Mohandas, D. Ullal Sheetal

Research output: Contribution to journalArticle

2 Citations (Scopus)


Objective: To assess the hepatoprotective and hepatoregenerative activity of Phyllanthusniruri in liver damage caused by long term administration of high doses of thioacetamide. Methods: Sixty, albino wistar male rats weighing 150 - 200g were divided into six groups of ten rats each. The study was conducted in two phases of twelve weeks each. Group I served as control. In group II hepatotoxicity was induced with thioacetamide during phase 1 and no active treatment was given in phase 2. In group III hepatotoxicity was induced during phase 1 and treatment with extract of Phyllanthusniruri was given in phase 2. In group IV hepatotoxicity was induced during both the phases. In group V Phyllanthusniruri was given in phase 1 and hepatotoxicity was induced during phase 2. Group VI received Phyllanthusniruriduring both the phases. Daily fluid intake and weekly body weight was measured. Histopathology and superoxide dismutase (SOD) activity of the liver were studied.Statistical analysis used: Data was analysed using SPSS software version 11.5. One way ANOVA followed by post hoc Tukey test was used. Data has been expressed as mean ± Standard deviation (SD), p value < 0.05 was considered significant. Results: There were four deaths in group II, two in group III and IV. All the rats in groups II, III and IV and 50% of the rats in group V developed cirrhosis; 50% of the rats in group also developed dysplasia. There was an increase in SOD activity in groups II and III and a decrease in the same in group IV. Conclusion: Phyllanthusniruri is an effective prophylactic against thioacetamide induced liver cirrhosis.

Original languageEnglish
Pages (from-to)341-343
Number of pages3
JournalInternational Journal of Pharmacy and Pharmaceutical Sciences
Issue number4
Publication statusPublished - 01-01-2014


All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science

Cite this