Hepatoprotective activity of Polygala elongata against CCl 4-induced hepatotoxicity in rats

A. Shirwaikar, R. Padma, A. Vasanth Kumar, L. Rao

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The ethanolic extract of the plant Polygala elongata Klein Ex.Willd (Polygalaceae) was investigated for its hepatoprotective activity in male Wistar rats. In acute toxicity studies, the extract when administered to mice as a single i.p. dose of 1000 mg/kg was found to be non toxic. The extract exhibited significant hepatoprotective activity at 200 mg/kg body weight, which was comparable to the activity exhibited by the reference standard, Silymarin in carbon tetrachloride-induced hepatoxicity model. Mangiferin, a xanthone, was the main component isolated from the ethyl methyl ketone fraction of the ethanolic extract. The flavonold, quercetin-3-O-β-D glucoside was also isolated from the ethyl acetate fraction.
Original languageEnglish
Pages (from-to)345-348
Number of pages4
JournalIndian Journal of Pharmaceutical Sciences
Volume64
Issue number4
Publication statusPublished - 2002

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Polygalaceae
Polygala
Silymarin
Carbon Tetrachloride
Poisons
Quercetin
Plant Extracts
Glucosides
Wistar Rats
Body Weight
mangiferin
xanthone
methylethyl ketone
ethyl acetate

Cite this

Shirwaikar, A. ; Padma, R. ; Vasanth Kumar, A. ; Rao, L. / Hepatoprotective activity of Polygala elongata against CCl 4-induced hepatotoxicity in rats. In: Indian Journal of Pharmaceutical Sciences. 2002 ; Vol. 64, No. 4. pp. 345-348.
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abstract = "The ethanolic extract of the plant Polygala elongata Klein Ex.Willd (Polygalaceae) was investigated for its hepatoprotective activity in male Wistar rats. In acute toxicity studies, the extract when administered to mice as a single i.p. dose of 1000 mg/kg was found to be non toxic. The extract exhibited significant hepatoprotective activity at 200 mg/kg body weight, which was comparable to the activity exhibited by the reference standard, Silymarin in carbon tetrachloride-induced hepatoxicity model. Mangiferin, a xanthone, was the main component isolated from the ethyl methyl ketone fraction of the ethanolic extract. The flavonold, quercetin-3-O-β-D glucoside was also isolated from the ethyl acetate fraction.",
author = "A. Shirwaikar and R. Padma and {Vasanth Kumar}, A. and L. Rao",
note = "Cited By :2 Export Date: 10 November 2017 CODEN: IJSID Correspondence Address: Shirwaikar, A.; Department of Pharmacognosy, College of Pharmaceutical Sciences, Manipal-576 119, India; email: annie.shirwaikar@cops.manipal.edu References: Chopra, R.N., Nayar, S.L., Chopra, I.C., (1956) Glossary of Indian Medicinal Plants, p. 21. , CSIR, Publication and Information Directorate, New Delhi; Maclean, A.E.M., (1975) Models of Liver Diseases, Karger, Tiffenia, p. 2. , Italy; Reitman, S., Frankel, S., (1975) Amer. J. Clin. Pathol, 28, p. 56; Kerman, A., (1955) J. Clin. Invest, 33, p. 131; Armilage, P., Berry, G., (1985) Statistical Methods in Medical Research, p. 186. , 2nd Edn, Blackwell Scientific Publications, Oxford; (1980) Remington's Pharmaceutical Sciences, p. 119. , Osol, A, Eds, 16th Edn, Mack Publishing Company, Pennsylvania; Recknagel, R.P. and Glende, E.A., CRC Critical Rev. Toxicology, 1973, 3, 263; Slater, T.F., (1966) Nature (London), 209, p. 36; Sherlock, S., (1981) Biochemical Assessment of Liver Function, p. 14. , Blackwell Scientific Publications, Oxford; Ghosal, S., Rao, G., (1996) Indian J. Chem, 35, p. 561; Soicke, H., Leng-Peschlow, E., (1987) Planta Med, 53, p. 37; Bezonger, L.B., Trupin, N., Guilbert, N., Guislin, R., (1964) C. R. Soc. Biol, 158, p. 2095",
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Shirwaikar, A, Padma, R, Vasanth Kumar, A & Rao, L 2002, 'Hepatoprotective activity of Polygala elongata against CCl 4-induced hepatotoxicity in rats', Indian Journal of Pharmaceutical Sciences, vol. 64, no. 4, pp. 345-348.

Hepatoprotective activity of Polygala elongata against CCl 4-induced hepatotoxicity in rats. / Shirwaikar, A.; Padma, R.; Vasanth Kumar, A.; Rao, L.

In: Indian Journal of Pharmaceutical Sciences, Vol. 64, No. 4, 2002, p. 345-348.

Research output: Contribution to journalArticle

TY - JOUR

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AU - Padma, R.

AU - Vasanth Kumar, A.

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N1 - Cited By :2 Export Date: 10 November 2017 CODEN: IJSID Correspondence Address: Shirwaikar, A.; Department of Pharmacognosy, College of Pharmaceutical Sciences, Manipal-576 119, India; email: annie.shirwaikar@cops.manipal.edu References: Chopra, R.N., Nayar, S.L., Chopra, I.C., (1956) Glossary of Indian Medicinal Plants, p. 21. , CSIR, Publication and Information Directorate, New Delhi; Maclean, A.E.M., (1975) Models of Liver Diseases, Karger, Tiffenia, p. 2. , Italy; Reitman, S., Frankel, S., (1975) Amer. J. Clin. Pathol, 28, p. 56; Kerman, A., (1955) J. Clin. Invest, 33, p. 131; Armilage, P., Berry, G., (1985) Statistical Methods in Medical Research, p. 186. , 2nd Edn, Blackwell Scientific Publications, Oxford; (1980) Remington's Pharmaceutical Sciences, p. 119. , Osol, A, Eds, 16th Edn, Mack Publishing Company, Pennsylvania; Recknagel, R.P. and Glende, E.A., CRC Critical Rev. Toxicology, 1973, 3, 263; Slater, T.F., (1966) Nature (London), 209, p. 36; Sherlock, S., (1981) Biochemical Assessment of Liver Function, p. 14. , Blackwell Scientific Publications, Oxford; Ghosal, S., Rao, G., (1996) Indian J. Chem, 35, p. 561; Soicke, H., Leng-Peschlow, E., (1987) Planta Med, 53, p. 37; Bezonger, L.B., Trupin, N., Guilbert, N., Guislin, R., (1964) C. R. Soc. Biol, 158, p. 2095

PY - 2002

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N2 - The ethanolic extract of the plant Polygala elongata Klein Ex.Willd (Polygalaceae) was investigated for its hepatoprotective activity in male Wistar rats. In acute toxicity studies, the extract when administered to mice as a single i.p. dose of 1000 mg/kg was found to be non toxic. The extract exhibited significant hepatoprotective activity at 200 mg/kg body weight, which was comparable to the activity exhibited by the reference standard, Silymarin in carbon tetrachloride-induced hepatoxicity model. Mangiferin, a xanthone, was the main component isolated from the ethyl methyl ketone fraction of the ethanolic extract. The flavonold, quercetin-3-O-β-D glucoside was also isolated from the ethyl acetate fraction.

AB - The ethanolic extract of the plant Polygala elongata Klein Ex.Willd (Polygalaceae) was investigated for its hepatoprotective activity in male Wistar rats. In acute toxicity studies, the extract when administered to mice as a single i.p. dose of 1000 mg/kg was found to be non toxic. The extract exhibited significant hepatoprotective activity at 200 mg/kg body weight, which was comparable to the activity exhibited by the reference standard, Silymarin in carbon tetrachloride-induced hepatoxicity model. Mangiferin, a xanthone, was the main component isolated from the ethyl methyl ketone fraction of the ethanolic extract. The flavonold, quercetin-3-O-β-D glucoside was also isolated from the ethyl acetate fraction.

M3 - Article

VL - 64

SP - 345

EP - 348

JO - Indian Journal of Pharmaceutical Sciences

JF - Indian Journal of Pharmaceutical Sciences

SN - 0250-474X

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ER -