Hepatoprotective activity of Terminalia paniculata against paracetamol induced hepatocellular damage in Wistar albino rats

B. R. Eesha, Amberkar V. Mohanbabu, Kumari K. Meena, Sarath babu, M. Vijay, M. Lalit, R. Rajput

Research output: Contribution to journalArticle

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Abstract

Objective: To evaluate the hepatoprotective activity of Terminalia paniculata against paracetamol induced hepatic damage in rats. Methods: The plant material was shade dried, powdered and extracted with ethanol. Liv 52 and silymarin were used as standard drugs and 2% gum acacia as a control (vehicle). Alteration in the levels of biochemical markers of hepatic damage like AST, ALT, ALP and lipid peroxides were tested, and phytochemical tests were also performed. Results: Paracetamol (2 g/kg) increased the serum levels of alanine aminotransfer (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and the lipid peroxides. Treatment of Liv 52, silymarin and ethanolic extract of Terminalia paniculata (200 mg/kg) altered levels of biochemical marker and showed significant hepatoprotective activity. Ethanolic extract revealed the presence of phenolic compound and flavanoids. Our findings suggested that ethanolic bark extract of Terminalia paniculata possessed hepatoprotective activity in a dose dependent manner. Conclusions: Terminalia paniculata possesses hepatoprotective activity. It could be an effective and promising preventive agent against PCT induced hepatotoxicity.

Original languageEnglish
Pages (from-to)466-469
Number of pages4
JournalAsian Pacific Journal of Tropical Medicine
Volume4
Issue number6
DOIs
Publication statusPublished - 01-06-2011

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Terminalia
Acetaminophen
Wistar Rats
Silymarin
Lipid Peroxides
Aspartate Aminotransferases
Alanine
Alkaline Phosphatase
Biomarkers
Gum Arabic
Liver
Phytochemicals
Ethanol
Serum
Pharmaceutical Preparations
Liv 52

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Eesha, B. R. ; Mohanbabu, Amberkar V. ; Meena, Kumari K. ; babu, Sarath ; Vijay, M. ; Lalit, M. ; Rajput, R. / Hepatoprotective activity of Terminalia paniculata against paracetamol induced hepatocellular damage in Wistar albino rats. In: Asian Pacific Journal of Tropical Medicine. 2011 ; Vol. 4, No. 6. pp. 466-469.
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Hepatoprotective activity of Terminalia paniculata against paracetamol induced hepatocellular damage in Wistar albino rats. / Eesha, B. R.; Mohanbabu, Amberkar V.; Meena, Kumari K.; babu, Sarath; Vijay, M.; Lalit, M.; Rajput, R.

In: Asian Pacific Journal of Tropical Medicine, Vol. 4, No. 6, 01.06.2011, p. 466-469.

Research output: Contribution to journalArticle

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