Hepatoprotective effect of root extracts of Tylophora Indica (wight & arn) against ethanol induced liver damage in rats

Nilesh Patel, Vipul Gujrati, T. S. Gouda, N. VenkatRao, K. Nandakumar, Md Shalam, S. M. Shanta Kumar

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Abstract

The aim of the present work was to study the hepatoprotective activity of alcoholic (ALRT) and aqueous (AQRT) extracts against ethanol induced liver damage in rats. Administration of ethanol (3.76 g/kg, bid, po) for 25 days produced significant changes in physical (increased liver weight and volume), biochemical (increase in serum GPT, GOT, ALP, direct bilirubin, total bilirubin, cholesterol, triglycerides with decrease in total protein and albumin levels), histological (damage to hepatocytes) and functional (increase in thiopentone induced sleeping time) parameters of liver, reflecting liver damage. Pretreatment with ALRT (125 and 300 mg/kg, bid, po) and AQRT (200 and 500 mg/kg, bid, po) 1 h before ethanol administration for 25 days significantly protected the physical, biochemical, histological and functional changes induced by ethanol. These results suggest that ALRT and AQRT protected the livers of rats against ethanol induced hepatic damage. ALRT was found to possess greater hepatoprotective activity than AQRT.

Original languageEnglish
Pages (from-to)57-62
Number of pages6
JournalToxicology International
Volume14
Issue number1
Publication statusPublished - 01-06-2007

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All Science Journal Classification (ASJC) codes

  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

Patel, N., Gujrati, V., Gouda, T. S., VenkatRao, N., Nandakumar, K., Shalam, M., & Shanta Kumar, S. M. (2007). Hepatoprotective effect of root extracts of Tylophora Indica (wight & arn) against ethanol induced liver damage in rats. Toxicology International, 14(1), 57-62.