@article{0b169aa053ed4b8fa2cf559dcf920831,
title = "Hepatoprotective potential of Fumaria indica Pugsley whole plant extracts, fractions and an isolated alkaloid protopine",
abstract = "The present investigation demonstrates the hepatoprotective potential of 50% ethanolic water extract of whole plant of Fumaria indica and its three fractions viz., hexane, chloroform and butanol against d-galactosamine induced hepatotoxicity in rats. The hepatoprotection was assessed in terms reduction in histological damage, changes in serum enzymes (SGOT, SGPT, ALP) and metabolites bilirubin, reduced glutathione (GSH) and lipid peroxidation (MDA content). Among fractions more than 90% protection was found with butanol fraction in which alkaloid protopine was quantified as highest i.e. about 0.2 mg/g by HPTLC. The isolated protopine in doses of 10-20 mg p.o. also proved equally effective hepatoprotectants as standard drug silymarine (single dose 25 mg p.o.). In general all treatments excluding hexane fraction proved hepatoprotective at par with silymarine (p≤0.01). {\textcopyright} 2007 Elsevier GmbH. All rights reserved.",
author = "A. Rathi and A.K. Srivastava and A. Shirwaikar and {Singh Rawat}, A.K. and S. Mehrotra",
note = "Cited By :36 Export Date: 10 November 2017 CODEN: PYTOE Correspondence Address: Rathi, A.; Pharmacognosy and Ethnopharmacology Division, National Botanical Research Institute, Lucknow, 226 001, India; email: anshurathi@rediffmail.com Chemicals/CAS: alanine aminotransferase, 9000-86-6, 9014-30-6; alkaline phosphatase, 9001-78-9; aspartate aminotransferase, 9000-97-9; bilirubin, 18422-02-1, 635-65-4; glutathione, 70-18-8; protopine, 130-86-9; silymarin, 65666-07-1; Benzophenanthridines; Berberine Alkaloids; Galactosamine, 7535-00-4; Plant Extracts; protopine, 130-86-9 Manufacturers: Sigma, United States References: Abdul-Hussain, S.K., Mehendale, H.M., Studies on the age dependant effect of galactosamine in primary rat hepatocyte cultures (1991) Toxicol. Appl. Pharmacol., 107, pp. 504-513; Anwar, H., Gilani, L., Khalid, H., Janbaz, E., Akhtar, S.M., Selective protective effect of an extract from Fumaria parviflora on paracetamol-induced hepatotoxicity (1996) Gen. 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year = "2008",
doi = "10.1016/j.phymed.2007.11.010",
language = "English",
volume = "15",
pages = "470--477",
journal = "Phytomedicine",
issn = "0944-7113",
publisher = "Urban und Fischer Verlag Jena",
number = "6-7",
}