Her-2 gene, receptors and drug target

A systematic review

Sadhana N. Holla, Veena Nayak, K. Laxminarayan Bairy, Amruta Tripathy, N. Shreedhar Holla

Research output: Contribution to journalReview article

6 Citations (Scopus)

Abstract

The discovery and identification of the human epidermal growth factor receptor 2 (HER’s-2) genes, have led to a better understanding of breast tumour biology. A member of the epidermal growth factor receptor family, it is a potent mediator of cellular growth and proliferation in malignant epithelial cells. Amplification or over expression of HER-2 occurs in approximately 15–30% of breast cancers and 10–30% of gastric/gastroesophageal cancers and serves as a prognostic and predictive biomarker. Treatment with HER-2 targeted monoclonal antibody, trastuzumab dramatically improved outcome in patients with breast malignancy. This promising approach led to the development of pertuzumab, ado-trastuzumab emtansine and lapatinib. The development of drug resistance and disease progression due to alternate signalling remained a real therapeutic challenge. Several research studies are currently focused on inhibition of onco-proteins, kinases and growth factors linked to HER-2 positive breast cancers. The success of immune checkpoint modulators and vaccines in preliminary studies describes the role of tumour immunity. Apart from its role in the pathogenesis of various cancers, HER-2 directed therapeutic approach has brought about a revolutionary change in terms of time to progression and survival rates in breast cancers.

Original languageEnglish
Pages (from-to)4-9
Number of pages6
JournalInternational Journal of Pharmacy and Pharmaceutical Sciences
Volume8
Issue number4
Publication statusPublished - 01-01-2016

Fingerprint

Drug Receptors
Breast Neoplasms
Genes
Stomach Neoplasms
erbB-2 Genes
Neoplasms
Epidermal Growth Factor Receptor
Drug Resistance
Protein Kinases
Disease Progression
Immunity
Intercellular Signaling Peptides and Proteins
Breast
Therapeutics
Vaccines
Survival Rate
Biomarkers
Epithelial Cells
Monoclonal Antibodies
Cell Proliferation

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science

Cite this

Holla, S. N., Nayak, V., Laxminarayan Bairy, K., Tripathy, A., & Shreedhar Holla, N. (2016). Her-2 gene, receptors and drug target: A systematic review. International Journal of Pharmacy and Pharmaceutical Sciences, 8(4), 4-9.
Holla, Sadhana N. ; Nayak, Veena ; Laxminarayan Bairy, K. ; Tripathy, Amruta ; Shreedhar Holla, N. / Her-2 gene, receptors and drug target : A systematic review. In: International Journal of Pharmacy and Pharmaceutical Sciences. 2016 ; Vol. 8, No. 4. pp. 4-9.
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Holla, SN, Nayak, V, Laxminarayan Bairy, K, Tripathy, A & Shreedhar Holla, N 2016, 'Her-2 gene, receptors and drug target: A systematic review', International Journal of Pharmacy and Pharmaceutical Sciences, vol. 8, no. 4, pp. 4-9.

Her-2 gene, receptors and drug target : A systematic review. / Holla, Sadhana N.; Nayak, Veena; Laxminarayan Bairy, K.; Tripathy, Amruta; Shreedhar Holla, N.

In: International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 8, No. 4, 01.01.2016, p. 4-9.

Research output: Contribution to journalReview article

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Holla SN, Nayak V, Laxminarayan Bairy K, Tripathy A, Shreedhar Holla N. Her-2 gene, receptors and drug target: A systematic review. International Journal of Pharmacy and Pharmaceutical Sciences. 2016 Jan 1;8(4):4-9.