Hesperidin inhibits nitrite-induced methemoglobin formation

M. Sudheer Kumar, K.K. Srinivasan, M.K. Unnikrishnan

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Hesperidin protects hemoglobin from nitrite-induced oxidation to methemoglobin. The protection was not observed when hesperidin was added after the autocatalytic stage of the oxidation of hemoglobin. The ability of hesperidin to scavenge superoxide may be responsible since superoxide is implicated in promoting the autocatalytic stage of oxidation of hemoglobin by nitrite.
Original languageEnglish
Pages (from-to)436-438
Number of pages3
JournalIndian Journal of Pharmaceutical Sciences
Volume65
Issue number4
Publication statusPublished - 2003

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Hesperidin
Methemoglobin
Nitrites
Hemoglobins
Superoxides

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Sudheer Kumar, M., Srinivasan, K. K., & Unnikrishnan, M. K. (2003). Hesperidin inhibits nitrite-induced methemoglobin formation. Indian Journal of Pharmaceutical Sciences, 65(4), 436-438.
Sudheer Kumar, M. ; Srinivasan, K.K. ; Unnikrishnan, M.K. / Hesperidin inhibits nitrite-induced methemoglobin formation. In: Indian Journal of Pharmaceutical Sciences. 2003 ; Vol. 65, No. 4. pp. 436-438.
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abstract = "Hesperidin protects hemoglobin from nitrite-induced oxidation to methemoglobin. The protection was not observed when hesperidin was added after the autocatalytic stage of the oxidation of hemoglobin. The ability of hesperidin to scavenge superoxide may be responsible since superoxide is implicated in promoting the autocatalytic stage of oxidation of hemoglobin by nitrite.",
author = "{Sudheer Kumar}, M. and K.K. Srinivasan and M.K. Unnikrishnan",
note = "Cited By :1 Export Date: 10 November 2017 CODEN: IJSID Correspondence Address: Unnikrishnan, M. K.; Department of Pharmacology, College of Pharmaceutical Sciences, Manipal-576 119, India; email: cheruvaloor@yahoo.com References: Chen, Y.T., Zheng, R.L., Jia, Z.J., Ju, Y., (1990) Free Radical Biol. Med, 9, p. 19; Ratty, A.K., Das, N.P., (1988) Biochem. Med. Metab. Biol, 39, p. 69; Doyle, M.P., Pickering, R.A., Dykstra, R.L., Nelson, C.L., Boyer, R.F., (1982) Biochem. Biophy. Res. Commun, 105, p. 127; Wallace, W.J., Houtchens, R.A., Maxwell, J.C., Caughey, W., (1982) J. Biol. Chem, 257, p. 4966; Tomoda, A., Tsuiji, A., Yoneyama, Y., (1981) Biochem. J, 193, p. 169; Unnikrishnan, M.K., Rao, M.N.A., (1992) FEBS Lett, 301, p. 195; Smith, R.C., Nunn, V., (1984) Arch. Biochem. Biophys, 232, p. 348",
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Sudheer Kumar, M, Srinivasan, KK & Unnikrishnan, MK 2003, 'Hesperidin inhibits nitrite-induced methemoglobin formation', Indian Journal of Pharmaceutical Sciences, vol. 65, no. 4, pp. 436-438.

Hesperidin inhibits nitrite-induced methemoglobin formation. / Sudheer Kumar, M.; Srinivasan, K.K.; Unnikrishnan, M.K.

In: Indian Journal of Pharmaceutical Sciences, Vol. 65, No. 4, 2003, p. 436-438.

Research output: Contribution to journalArticle

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AU - Srinivasan, K.K.

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PY - 2003

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AB - Hesperidin protects hemoglobin from nitrite-induced oxidation to methemoglobin. The protection was not observed when hesperidin was added after the autocatalytic stage of the oxidation of hemoglobin. The ability of hesperidin to scavenge superoxide may be responsible since superoxide is implicated in promoting the autocatalytic stage of oxidation of hemoglobin by nitrite.

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Sudheer Kumar M, Srinivasan KK, Unnikrishnan MK. Hesperidin inhibits nitrite-induced methemoglobin formation. Indian Journal of Pharmaceutical Sciences. 2003;65(4):436-438.