High-dose thiamine strategy in Wernicke-Korsakoff syndrome and related thiamine deficiency conditions associated with alcohol use disorder

Samir Praharaj, Ravindra Munoli, Sonia Shenoy, Suma Udupa, Linda Thomas

Research output: Contribution to journalReview articlepeer-review

Abstract

Thiamine is essential for the activity of several enzymes associated with energy metabolism in humans. Chronic alcohol use is associated with deficiency of thiamine along with other vitamins through several mechanisms. Several neuropsychiatric syndromes have been associated with thiamine deficiency in the context of alcohol use disorder including Wernicke-Korsakoff syndrome, alcoholic cerebellar syndrome, alcoholic peripheral neuropathy, and possibly, Marchiafava-Bignami syndrome. High-dose thiamine replacement is suggested for these neuropsychiatric syndromes.

Original languageEnglish
Pages (from-to)121-126
Number of pages6
JournalIndian Journal of Psychiatry
Volume63
Issue number2
DOIs
Publication statusPublished - 01-03-2021

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health

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