High glucose modulates IL-6 mediated immune homeostasis through impeding neutrophil extracellular trap formation

Manjunath B. Joshi, Apurva Lad, Alevoor S. Bharath Prasad, Aswath Balakrishnan, Lingadakai Ramachandra, Kapaettu Satyamoorthy

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

Neutrophils serve as an active constituent of innate immunity and are endowed with distinct ability for producing neutrophil extracellular traps (NETs) to eliminate pathogens. Earlier studies have demonstrated a dysfunction of the innate immune system in diabetic subjects leading to increased susceptibility to infections; however, the influence of hyperglycemic conditions on NETs is unknown. In the present study we demonstrate that (a) NETs are influenced by glucose homeostasis, (b) IL-6 is a potent inducer of energy dependent NET formation and (c) hyperglycemia mimics a state of constitutively active pro-inflammatory condition in neutrophils leading to reduced response to external stimuli making diabetic subjects susceptible to infections.

Original languageEnglish
Pages (from-to)2241-2246
Number of pages6
JournalFEBS Letters
Volume587
Issue number14
DOIs
Publication statusPublished - 11-07-2013

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Biophysics
  • Cell Biology
  • Genetics
  • Molecular Biology
  • Structural Biology

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