High-sensitive C-reactive protein levels in diabetes associated with dyslipidemia

Yousef Rezaei Chianeh, Krishnananda Prabhu, Vinutha R. Bhat, Padmanabha Udupa, Azadeh Bagheri, Shivananda Baliga, Ravi Teja Chelikani

Research output: Contribution to journalArticle

Abstract

Background: There is compelling evidence that inflammation is an important risk factor in cardiovascular disease (CVD) and diabetes mellitus. High-sensitive C-reactive protein (hs-CRP) is a predictive marker of inflammation as well as metabolic syndrome. Aims and Objectives: The purpose of this study was to correlate the significance of hs-CRP with cholesterol, triglyceride (TG), high density lipoprotein cholesterol (HDL-C), and low density lipoprotein (LDL) in patients with long-term hyperglycemia and healthy control group. Materials and Methods: This study involved 311 subjects (150 patients, 161 control group; between 40 and 65 years of age, mean age of patients and control group were 51.4 ± 9.6, 45.96 ± 3, respectively). Serum concentration of aforementioned analytes was measured among the patients and controls. Results: The concentration of parameters among case and control group were total cholesterol (227.84 ± 28.3, 167.45 ± 21.63 mg/dl), LDL cholesterol (158.43 ± 25.65, 117.30 ± 31.27 mg/dl), HDL-C (27.67 ± 11.11, 51.74 ± 12.61 mg/dl), TG (211.34 ± 36.42, 98.13 ± 67.40 mg/dl), and hs-CRP (29.49 ± 5.90, 2.18 ± 1.10 mg/L) were measured by Cobas 6000 autoanalyzer. A statistically significant (P < 0.001) difference was found in both groups. Conclusion: Diabetes mellitus has a profound effect on lipid metabolism and patient’s lipid profile need to be monitored and managed frequently to prevent further complication such as CVD that may arise as a result of dyslipidemia.

Original languageEnglish
Pages (from-to)480-483
Number of pages4
JournalNational Journal of Physiology, Pharmacy and Pharmacology
Volume6
Issue number5
DOIs
Publication statusPublished - 01-01-2016

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Dyslipidemias
C-Reactive Protein
Control Groups
HDL Cholesterol
Diabetes Mellitus
Triglycerides
Cardiovascular Diseases
Cholesterol
Inflammation
LDL Lipoproteins
Lipid Metabolism
Hyperglycemia
LDL Cholesterol
Age Groups
Lipids
Serum

All Science Journal Classification (ASJC) codes

  • Physiology
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

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title = "High-sensitive C-reactive protein levels in diabetes associated with dyslipidemia",
abstract = "Background: There is compelling evidence that inflammation is an important risk factor in cardiovascular disease (CVD) and diabetes mellitus. High-sensitive C-reactive protein (hs-CRP) is a predictive marker of inflammation as well as metabolic syndrome. Aims and Objectives: The purpose of this study was to correlate the significance of hs-CRP with cholesterol, triglyceride (TG), high density lipoprotein cholesterol (HDL-C), and low density lipoprotein (LDL) in patients with long-term hyperglycemia and healthy control group. Materials and Methods: This study involved 311 subjects (150 patients, 161 control group; between 40 and 65 years of age, mean age of patients and control group were 51.4 ± 9.6, 45.96 ± 3, respectively). Serum concentration of aforementioned analytes was measured among the patients and controls. Results: The concentration of parameters among case and control group were total cholesterol (227.84 ± 28.3, 167.45 ± 21.63 mg/dl), LDL cholesterol (158.43 ± 25.65, 117.30 ± 31.27 mg/dl), HDL-C (27.67 ± 11.11, 51.74 ± 12.61 mg/dl), TG (211.34 ± 36.42, 98.13 ± 67.40 mg/dl), and hs-CRP (29.49 ± 5.90, 2.18 ± 1.10 mg/L) were measured by Cobas 6000 autoanalyzer. A statistically significant (P < 0.001) difference was found in both groups. Conclusion: Diabetes mellitus has a profound effect on lipid metabolism and patient’s lipid profile need to be monitored and managed frequently to prevent further complication such as CVD that may arise as a result of dyslipidemia.",
author = "Chianeh, {Yousef Rezaei} and Krishnananda Prabhu and Bhat, {Vinutha R.} and Padmanabha Udupa and Azadeh Bagheri and Shivananda Baliga and Chelikani, {Ravi Teja}",
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High-sensitive C-reactive protein levels in diabetes associated with dyslipidemia. / Chianeh, Yousef Rezaei; Prabhu, Krishnananda; Bhat, Vinutha R.; Udupa, Padmanabha; Bagheri, Azadeh; Baliga, Shivananda; Chelikani, Ravi Teja.

In: National Journal of Physiology, Pharmacy and Pharmacology, Vol. 6, No. 5, 01.01.2016, p. 480-483.

Research output: Contribution to journalArticle

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T1 - High-sensitive C-reactive protein levels in diabetes associated with dyslipidemia

AU - Chianeh, Yousef Rezaei

AU - Prabhu, Krishnananda

AU - Bhat, Vinutha R.

AU - Udupa, Padmanabha

AU - Bagheri, Azadeh

AU - Baliga, Shivananda

AU - Chelikani, Ravi Teja

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Background: There is compelling evidence that inflammation is an important risk factor in cardiovascular disease (CVD) and diabetes mellitus. High-sensitive C-reactive protein (hs-CRP) is a predictive marker of inflammation as well as metabolic syndrome. Aims and Objectives: The purpose of this study was to correlate the significance of hs-CRP with cholesterol, triglyceride (TG), high density lipoprotein cholesterol (HDL-C), and low density lipoprotein (LDL) in patients with long-term hyperglycemia and healthy control group. Materials and Methods: This study involved 311 subjects (150 patients, 161 control group; between 40 and 65 years of age, mean age of patients and control group were 51.4 ± 9.6, 45.96 ± 3, respectively). Serum concentration of aforementioned analytes was measured among the patients and controls. Results: The concentration of parameters among case and control group were total cholesterol (227.84 ± 28.3, 167.45 ± 21.63 mg/dl), LDL cholesterol (158.43 ± 25.65, 117.30 ± 31.27 mg/dl), HDL-C (27.67 ± 11.11, 51.74 ± 12.61 mg/dl), TG (211.34 ± 36.42, 98.13 ± 67.40 mg/dl), and hs-CRP (29.49 ± 5.90, 2.18 ± 1.10 mg/L) were measured by Cobas 6000 autoanalyzer. A statistically significant (P < 0.001) difference was found in both groups. Conclusion: Diabetes mellitus has a profound effect on lipid metabolism and patient’s lipid profile need to be monitored and managed frequently to prevent further complication such as CVD that may arise as a result of dyslipidemia.

AB - Background: There is compelling evidence that inflammation is an important risk factor in cardiovascular disease (CVD) and diabetes mellitus. High-sensitive C-reactive protein (hs-CRP) is a predictive marker of inflammation as well as metabolic syndrome. Aims and Objectives: The purpose of this study was to correlate the significance of hs-CRP with cholesterol, triglyceride (TG), high density lipoprotein cholesterol (HDL-C), and low density lipoprotein (LDL) in patients with long-term hyperglycemia and healthy control group. Materials and Methods: This study involved 311 subjects (150 patients, 161 control group; between 40 and 65 years of age, mean age of patients and control group were 51.4 ± 9.6, 45.96 ± 3, respectively). Serum concentration of aforementioned analytes was measured among the patients and controls. Results: The concentration of parameters among case and control group were total cholesterol (227.84 ± 28.3, 167.45 ± 21.63 mg/dl), LDL cholesterol (158.43 ± 25.65, 117.30 ± 31.27 mg/dl), HDL-C (27.67 ± 11.11, 51.74 ± 12.61 mg/dl), TG (211.34 ± 36.42, 98.13 ± 67.40 mg/dl), and hs-CRP (29.49 ± 5.90, 2.18 ± 1.10 mg/L) were measured by Cobas 6000 autoanalyzer. A statistically significant (P < 0.001) difference was found in both groups. Conclusion: Diabetes mellitus has a profound effect on lipid metabolism and patient’s lipid profile need to be monitored and managed frequently to prevent further complication such as CVD that may arise as a result of dyslipidemia.

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