Hindering effect of resveratrol on oxidative changes and Na+ K+-ATPase activity in rat hepatocytes exposed to prenatal stress

Research output: Contribution to journalArticle

Abstract

Introduction: The fetal programming hypothesis states that conditions during pregnancy, including stress, will have long-term effects on adult health, probably via epigenetic mechanisms. Methodology: Pregnant rats were subjected to restrain stress either during early or late pregnancy with and without resveratrol. Blood and liver tissues were collected from 40 days old offsprings of the above rats to study the prenatal effect on corticosterone, and stress development. Results: It was found that levels of corticosterone advanced protein and lipid oxidation products, GSHRx, increase significantly in offsprings of stressed rats and decreased on intervention with resveratrol, whereas total antioxidants, vitamin C, GSH, SOD and Na+K+- ATPase decreased with stress and increase on resveratrol intervention as compared to controls. Conclusion: The alterations may be due to the effect of stress on HPA axis. Results also support the prevention/protective effect of resveratrol on oxidative stress and may be used as a measure to prevent the metabolic changes in adult life due to prenatal stress.

Original languageEnglish
Pages (from-to)615-620
Number of pages6
JournalPharmacognosy Journal
Volume9
Issue number5
DOIs
Publication statusPublished - 01-09-2017

Fingerprint

Hepatocytes
Corticosterone
Advanced Oxidation Protein Products
Pregnancy
Fetal Development
Epigenomics
Ascorbic Acid
Oxidative Stress
Antioxidants
Lipids
resveratrol
sodium-translocating ATPase
Liver
Health

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery

Cite this

@article{ca1abc37454544c8b6340241b3a3f6b6,
title = "Hindering effect of resveratrol on oxidative changes and Na+ K+-ATPase activity in rat hepatocytes exposed to prenatal stress",
abstract = "Introduction: The fetal programming hypothesis states that conditions during pregnancy, including stress, will have long-term effects on adult health, probably via epigenetic mechanisms. Methodology: Pregnant rats were subjected to restrain stress either during early or late pregnancy with and without resveratrol. Blood and liver tissues were collected from 40 days old offsprings of the above rats to study the prenatal effect on corticosterone, and stress development. Results: It was found that levels of corticosterone advanced protein and lipid oxidation products, GSHRx, increase significantly in offsprings of stressed rats and decreased on intervention with resveratrol, whereas total antioxidants, vitamin C, GSH, SOD and Na+K+- ATPase decreased with stress and increase on resveratrol intervention as compared to controls. Conclusion: The alterations may be due to the effect of stress on HPA axis. Results also support the prevention/protective effect of resveratrol on oxidative stress and may be used as a measure to prevent the metabolic changes in adult life due to prenatal stress.",
author = "Rao, {Gayathri Megashyam} and Sahu, {Sudhanshu Sekhar} and Shetty, {Beena Vichithra}",
year = "2017",
month = "9",
day = "1",
doi = "10.5530/pj.2017.5.98",
language = "English",
volume = "9",
pages = "615--620",
journal = "Pharmacognosy Journal",
issn = "0975-3575",
publisher = "Pharmacognosy Network Worldwide",
number = "5",

}

TY - JOUR

T1 - Hindering effect of resveratrol on oxidative changes and Na+ K+-ATPase activity in rat hepatocytes exposed to prenatal stress

AU - Rao, Gayathri Megashyam

AU - Sahu, Sudhanshu Sekhar

AU - Shetty, Beena Vichithra

PY - 2017/9/1

Y1 - 2017/9/1

N2 - Introduction: The fetal programming hypothesis states that conditions during pregnancy, including stress, will have long-term effects on adult health, probably via epigenetic mechanisms. Methodology: Pregnant rats were subjected to restrain stress either during early or late pregnancy with and without resveratrol. Blood and liver tissues were collected from 40 days old offsprings of the above rats to study the prenatal effect on corticosterone, and stress development. Results: It was found that levels of corticosterone advanced protein and lipid oxidation products, GSHRx, increase significantly in offsprings of stressed rats and decreased on intervention with resveratrol, whereas total antioxidants, vitamin C, GSH, SOD and Na+K+- ATPase decreased with stress and increase on resveratrol intervention as compared to controls. Conclusion: The alterations may be due to the effect of stress on HPA axis. Results also support the prevention/protective effect of resveratrol on oxidative stress and may be used as a measure to prevent the metabolic changes in adult life due to prenatal stress.

AB - Introduction: The fetal programming hypothesis states that conditions during pregnancy, including stress, will have long-term effects on adult health, probably via epigenetic mechanisms. Methodology: Pregnant rats were subjected to restrain stress either during early or late pregnancy with and without resveratrol. Blood and liver tissues were collected from 40 days old offsprings of the above rats to study the prenatal effect on corticosterone, and stress development. Results: It was found that levels of corticosterone advanced protein and lipid oxidation products, GSHRx, increase significantly in offsprings of stressed rats and decreased on intervention with resveratrol, whereas total antioxidants, vitamin C, GSH, SOD and Na+K+- ATPase decreased with stress and increase on resveratrol intervention as compared to controls. Conclusion: The alterations may be due to the effect of stress on HPA axis. Results also support the prevention/protective effect of resveratrol on oxidative stress and may be used as a measure to prevent the metabolic changes in adult life due to prenatal stress.

UR - http://www.scopus.com/inward/record.url?scp=85039695317&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85039695317&partnerID=8YFLogxK

U2 - 10.5530/pj.2017.5.98

DO - 10.5530/pj.2017.5.98

M3 - Article

AN - SCOPUS:85039695317

VL - 9

SP - 615

EP - 620

JO - Pharmacognosy Journal

JF - Pharmacognosy Journal

SN - 0975-3575

IS - 5

ER -