Hippocampal neurogenesis in the prenatally stressed rat is enhanced by resveratrol treatment

M. Sampath, S. Sudhanshu, J. Teresa, K. Rachana, R. Ashwin, P. Divya

Research output: Contribution to journalArticle

Abstract

An increasing number of reports have provided correlational evidence that prenatal stress caused a suppressed hippocampal neurogenesis. Resveratrol, a polyphenolic activator of sirtuin 1, is known to exert its neuroprotective potential by enhancing neurogenesis in hippocampus. But the efficacy of resveratrol against prenatal stress was not studied to the best of our knowledge. To address this issue we evaluated the neuroprotective action of resveratrol on prenatal stress-induced impaired neurogenesis. Pregnant rats were subjected to restraint stress during early or late gestational period. Another sets of rats received resveratrol during entire gestational period along with early or late gestational stress. Neurogenesis in the hippocampus was assessed by using a neuronal marker doublecortin on 21st postnatal day. Both early and late gestational stress resulted in significant decrease in neurogenesis and in hippocampus. The decrease of neurogenesis was more profound in the offspring who received late gestational stress compared to early gestational stress Resveratrol treatment has improved the neurogenesis. These data suggest the neuroprotective efficacy of resveratrol against prenatal stress induced impaired neurogenesis.

Original languageEnglish
Pages (from-to)141-148
Number of pages8
JournalPharmacologyonline
Volume2
Publication statusPublished - 24-10-2013
Externally publishedYes

Fingerprint

Neurogenesis
Hippocampus
Sirtuin 1
resveratrol

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery

Cite this

Sampath, M., Sudhanshu, S., Teresa, J., Rachana, K., Ashwin, R., & Divya, P. (2013). Hippocampal neurogenesis in the prenatally stressed rat is enhanced by resveratrol treatment. Pharmacologyonline, 2, 141-148.
Sampath, M. ; Sudhanshu, S. ; Teresa, J. ; Rachana, K. ; Ashwin, R. ; Divya, P. / Hippocampal neurogenesis in the prenatally stressed rat is enhanced by resveratrol treatment. In: Pharmacologyonline. 2013 ; Vol. 2. pp. 141-148.
@article{7342c72de3e34073ad1c5315c537db6f,
title = "Hippocampal neurogenesis in the prenatally stressed rat is enhanced by resveratrol treatment",
abstract = "An increasing number of reports have provided correlational evidence that prenatal stress caused a suppressed hippocampal neurogenesis. Resveratrol, a polyphenolic activator of sirtuin 1, is known to exert its neuroprotective potential by enhancing neurogenesis in hippocampus. But the efficacy of resveratrol against prenatal stress was not studied to the best of our knowledge. To address this issue we evaluated the neuroprotective action of resveratrol on prenatal stress-induced impaired neurogenesis. Pregnant rats were subjected to restraint stress during early or late gestational period. Another sets of rats received resveratrol during entire gestational period along with early or late gestational stress. Neurogenesis in the hippocampus was assessed by using a neuronal marker doublecortin on 21st postnatal day. Both early and late gestational stress resulted in significant decrease in neurogenesis and in hippocampus. The decrease of neurogenesis was more profound in the offspring who received late gestational stress compared to early gestational stress Resveratrol treatment has improved the neurogenesis. These data suggest the neuroprotective efficacy of resveratrol against prenatal stress induced impaired neurogenesis.",
author = "M. Sampath and S. Sudhanshu and J. Teresa and K. Rachana and R. Ashwin and P. Divya",
year = "2013",
month = "10",
day = "24",
language = "English",
volume = "2",
pages = "141--148",
journal = "Pharmacologyonline",
issn = "1827-8620",
publisher = "SILAE (Italo-Latin American Society of Ethnomedicine)",

}

Sampath, M, Sudhanshu, S, Teresa, J, Rachana, K, Ashwin, R & Divya, P 2013, 'Hippocampal neurogenesis in the prenatally stressed rat is enhanced by resveratrol treatment', Pharmacologyonline, vol. 2, pp. 141-148.

Hippocampal neurogenesis in the prenatally stressed rat is enhanced by resveratrol treatment. / Sampath, M.; Sudhanshu, S.; Teresa, J.; Rachana, K.; Ashwin, R.; Divya, P.

In: Pharmacologyonline, Vol. 2, 24.10.2013, p. 141-148.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Hippocampal neurogenesis in the prenatally stressed rat is enhanced by resveratrol treatment

AU - Sampath, M.

AU - Sudhanshu, S.

AU - Teresa, J.

AU - Rachana, K.

AU - Ashwin, R.

AU - Divya, P.

PY - 2013/10/24

Y1 - 2013/10/24

N2 - An increasing number of reports have provided correlational evidence that prenatal stress caused a suppressed hippocampal neurogenesis. Resveratrol, a polyphenolic activator of sirtuin 1, is known to exert its neuroprotective potential by enhancing neurogenesis in hippocampus. But the efficacy of resveratrol against prenatal stress was not studied to the best of our knowledge. To address this issue we evaluated the neuroprotective action of resveratrol on prenatal stress-induced impaired neurogenesis. Pregnant rats were subjected to restraint stress during early or late gestational period. Another sets of rats received resveratrol during entire gestational period along with early or late gestational stress. Neurogenesis in the hippocampus was assessed by using a neuronal marker doublecortin on 21st postnatal day. Both early and late gestational stress resulted in significant decrease in neurogenesis and in hippocampus. The decrease of neurogenesis was more profound in the offspring who received late gestational stress compared to early gestational stress Resveratrol treatment has improved the neurogenesis. These data suggest the neuroprotective efficacy of resveratrol against prenatal stress induced impaired neurogenesis.

AB - An increasing number of reports have provided correlational evidence that prenatal stress caused a suppressed hippocampal neurogenesis. Resveratrol, a polyphenolic activator of sirtuin 1, is known to exert its neuroprotective potential by enhancing neurogenesis in hippocampus. But the efficacy of resveratrol against prenatal stress was not studied to the best of our knowledge. To address this issue we evaluated the neuroprotective action of resveratrol on prenatal stress-induced impaired neurogenesis. Pregnant rats were subjected to restraint stress during early or late gestational period. Another sets of rats received resveratrol during entire gestational period along with early or late gestational stress. Neurogenesis in the hippocampus was assessed by using a neuronal marker doublecortin on 21st postnatal day. Both early and late gestational stress resulted in significant decrease in neurogenesis and in hippocampus. The decrease of neurogenesis was more profound in the offspring who received late gestational stress compared to early gestational stress Resveratrol treatment has improved the neurogenesis. These data suggest the neuroprotective efficacy of resveratrol against prenatal stress induced impaired neurogenesis.

UR - http://www.scopus.com/inward/record.url?scp=84885916900&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84885916900&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:84885916900

VL - 2

SP - 141

EP - 148

JO - Pharmacologyonline

JF - Pharmacologyonline

SN - 1827-8620

ER -

Sampath M, Sudhanshu S, Teresa J, Rachana K, Ashwin R, Divya P. Hippocampal neurogenesis in the prenatally stressed rat is enhanced by resveratrol treatment. Pharmacologyonline. 2013 Oct 24;2:141-148.