Histomorphologic spectrum in hyaline vascular variant of castleman disease

Chaithra Gowthuvalli Venkataramana, Hema Kini, Debarshi Saha, Sharada Rai, Deepa Sowkur Anandarama Adiga, Ranjitha Rao, Cheryl Sarah Philipose

Research output: Contribution to journalArticle

Abstract

Introduction: Castleman Disease (CD) is a rare lymphoproliferative disorder with heterogenous clinical and pathological features. It is a rare disease with mention in the rare disease data of the orpha net. It can present as unicentric or multicentric disease. Hyaline vascular variant and plasma cell variant are the two pathological subtypes. Hyaline vascular variant accounts for nearly 80% to 90% of unicentric cases. Hyaline vascular subtype variant has follicular and stroma rich subtype. Aim: To study the histomorphologic spectrum of hyaline vascular variant of CD. Materials and Methods: Retrospective cross-sectional, observational study was undertaken from the archival data between January 2009 and April 2015. Only ten cases of hyaline vascular CD were identified after studying the histomorphological characteristics. Both follicular and interfollicular changes were studied in detail. Results: The age of presentation ranged from 17 years to 59 years. Seven out of 10 cases were female. Site of presentation included cervical, inguinal, retroperitoneal, intra-abdominal and axillary. Six cases showed predominant follicular change. Two cases were sclerotic subtype. Two cases showed both follicular and interfollicular changes in equal proportion. Distribution of follicles throughout the lymphnode was seen in eight cases. Uniform sized follicles seen in seven out of ten cases. Small germinal centre with lymphocyte depletion was one of the uniform features seen in all 10 cases. Numerous high endothelial vessels were seen in nine cases. Twinning of germinal centre was seen in two cases. All ten cases showed concentric rings of small lymphocytes. Lollipop pattern was relatively rare feature seen in only two cases. Conclusion: Hyaline vascular variant of CD has considerable morphologic variation with few consistent features seen in most of the cases.

Original languageEnglish
Pages (from-to)EC01-EC04
JournalJournal of Clinical and Diagnostic Research
Volume11
Issue number8
DOIs
Publication statusPublished - 01-08-2017

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Giant Lymph Node Hyperplasia
Hyalin
Blood Vessels
Germinal Center
Rare Diseases
Lymphocytes
Lymphocyte Depletion
Lymphoproliferative Disorders
Groin
Plasma Cells
Vascular Diseases
Twinning
Observational Studies
Cross-Sectional Studies
Plasmas

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry

Cite this

Venkataramana, Chaithra Gowthuvalli ; Kini, Hema ; Saha, Debarshi ; Rai, Sharada ; Adiga, Deepa Sowkur Anandarama ; Rao, Ranjitha ; Philipose, Cheryl Sarah. / Histomorphologic spectrum in hyaline vascular variant of castleman disease. In: Journal of Clinical and Diagnostic Research. 2017 ; Vol. 11, No. 8. pp. EC01-EC04.
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abstract = "Introduction: Castleman Disease (CD) is a rare lymphoproliferative disorder with heterogenous clinical and pathological features. It is a rare disease with mention in the rare disease data of the orpha net. It can present as unicentric or multicentric disease. Hyaline vascular variant and plasma cell variant are the two pathological subtypes. Hyaline vascular variant accounts for nearly 80{\%} to 90{\%} of unicentric cases. Hyaline vascular subtype variant has follicular and stroma rich subtype. Aim: To study the histomorphologic spectrum of hyaline vascular variant of CD. Materials and Methods: Retrospective cross-sectional, observational study was undertaken from the archival data between January 2009 and April 2015. Only ten cases of hyaline vascular CD were identified after studying the histomorphological characteristics. Both follicular and interfollicular changes were studied in detail. Results: The age of presentation ranged from 17 years to 59 years. Seven out of 10 cases were female. Site of presentation included cervical, inguinal, retroperitoneal, intra-abdominal and axillary. Six cases showed predominant follicular change. Two cases were sclerotic subtype. Two cases showed both follicular and interfollicular changes in equal proportion. Distribution of follicles throughout the lymphnode was seen in eight cases. Uniform sized follicles seen in seven out of ten cases. Small germinal centre with lymphocyte depletion was one of the uniform features seen in all 10 cases. Numerous high endothelial vessels were seen in nine cases. Twinning of germinal centre was seen in two cases. All ten cases showed concentric rings of small lymphocytes. Lollipop pattern was relatively rare feature seen in only two cases. Conclusion: Hyaline vascular variant of CD has considerable morphologic variation with few consistent features seen in most of the cases.",
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Histomorphologic spectrum in hyaline vascular variant of castleman disease. / Venkataramana, Chaithra Gowthuvalli; Kini, Hema; Saha, Debarshi; Rai, Sharada; Adiga, Deepa Sowkur Anandarama; Rao, Ranjitha; Philipose, Cheryl Sarah.

In: Journal of Clinical and Diagnostic Research, Vol. 11, No. 8, 01.08.2017, p. EC01-EC04.

Research output: Contribution to journalArticle

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T1 - Histomorphologic spectrum in hyaline vascular variant of castleman disease

AU - Venkataramana, Chaithra Gowthuvalli

AU - Kini, Hema

AU - Saha, Debarshi

AU - Rai, Sharada

AU - Adiga, Deepa Sowkur Anandarama

AU - Rao, Ranjitha

AU - Philipose, Cheryl Sarah

PY - 2017/8/1

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N2 - Introduction: Castleman Disease (CD) is a rare lymphoproliferative disorder with heterogenous clinical and pathological features. It is a rare disease with mention in the rare disease data of the orpha net. It can present as unicentric or multicentric disease. Hyaline vascular variant and plasma cell variant are the two pathological subtypes. Hyaline vascular variant accounts for nearly 80% to 90% of unicentric cases. Hyaline vascular subtype variant has follicular and stroma rich subtype. Aim: To study the histomorphologic spectrum of hyaline vascular variant of CD. Materials and Methods: Retrospective cross-sectional, observational study was undertaken from the archival data between January 2009 and April 2015. Only ten cases of hyaline vascular CD were identified after studying the histomorphological characteristics. Both follicular and interfollicular changes were studied in detail. Results: The age of presentation ranged from 17 years to 59 years. Seven out of 10 cases were female. Site of presentation included cervical, inguinal, retroperitoneal, intra-abdominal and axillary. Six cases showed predominant follicular change. Two cases were sclerotic subtype. Two cases showed both follicular and interfollicular changes in equal proportion. Distribution of follicles throughout the lymphnode was seen in eight cases. Uniform sized follicles seen in seven out of ten cases. Small germinal centre with lymphocyte depletion was one of the uniform features seen in all 10 cases. Numerous high endothelial vessels were seen in nine cases. Twinning of germinal centre was seen in two cases. All ten cases showed concentric rings of small lymphocytes. Lollipop pattern was relatively rare feature seen in only two cases. Conclusion: Hyaline vascular variant of CD has considerable morphologic variation with few consistent features seen in most of the cases.

AB - Introduction: Castleman Disease (CD) is a rare lymphoproliferative disorder with heterogenous clinical and pathological features. It is a rare disease with mention in the rare disease data of the orpha net. It can present as unicentric or multicentric disease. Hyaline vascular variant and plasma cell variant are the two pathological subtypes. Hyaline vascular variant accounts for nearly 80% to 90% of unicentric cases. Hyaline vascular subtype variant has follicular and stroma rich subtype. Aim: To study the histomorphologic spectrum of hyaline vascular variant of CD. Materials and Methods: Retrospective cross-sectional, observational study was undertaken from the archival data between January 2009 and April 2015. Only ten cases of hyaline vascular CD were identified after studying the histomorphological characteristics. Both follicular and interfollicular changes were studied in detail. Results: The age of presentation ranged from 17 years to 59 years. Seven out of 10 cases were female. Site of presentation included cervical, inguinal, retroperitoneal, intra-abdominal and axillary. Six cases showed predominant follicular change. Two cases were sclerotic subtype. Two cases showed both follicular and interfollicular changes in equal proportion. Distribution of follicles throughout the lymphnode was seen in eight cases. Uniform sized follicles seen in seven out of ten cases. Small germinal centre with lymphocyte depletion was one of the uniform features seen in all 10 cases. Numerous high endothelial vessels were seen in nine cases. Twinning of germinal centre was seen in two cases. All ten cases showed concentric rings of small lymphocytes. Lollipop pattern was relatively rare feature seen in only two cases. Conclusion: Hyaline vascular variant of CD has considerable morphologic variation with few consistent features seen in most of the cases.

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