Histone demethylase KDM5B as a therapeutic target for cancer therapy

Anmi Jose, Gautham G. Shenoy, Gabriel Sunil Rodrigues, Naveena A.N. Kumar, Murali Munisamy, Levin Thomas, Jill Kolesar, Ganesha Rai, Praveen P.N. Rao, Mahadev Rao

Research output: Contribution to journalReview articlepeer-review

9 Citations (Scopus)

Abstract

Lysine-specific demethylase 5B (KDM5B/PLU1/JARID1B) is found to be overexpressed in numerous malignancies, including breast, lung, skin, liver, and prostate cancer. Identification of molecules targeting the KDM5B enzyme could be a potential lead in cancer research. Although many KDM5B inhibitors with promising outcomes have been developed so far, its further application in clinical practice is limited due to toxicity and lack of target specificity. Here, we summarize the significance of targeting KDM5B in anticancer therapy and report the molecular docking studies of some known anti-viral agents, decitabine, entecavir, abacavir, penciclovir, and 3-deazaneplanocin A in the catalytic domain JmjC of KDM5B. These studies show the repurposing potential of identified anti-viral agents in cancer therapy.

Original languageEnglish
Article number2121
Pages (from-to)1-16
Number of pages16
JournalCancers
Volume12
Issue number8
DOIs
Publication statusPublished - 08-2020

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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