Hot-Melt Extrusion: An Emerging Technique for Solubility Enhancement of Poorly Water-Soluble Drugs

Amit Chivate, Atul Garkal, Namdev Dhas, Tejal Mehta

Research output: Contribution to journalReview articlepeer-review

11 Citations (Scopus)

Abstract

The solubility of the drug is a significant aspect to be considered during manufacturing of pharmaceutical products. Poor aqueous solubility of drugs imparts depleted bioavailability. In this regard, several techniques are available for enhancing drug solubility or dissolution. However, only few of them are scalable and industrially applicable. Hot-melt extrusion (HME) is one such technique that has been widely used in the industry. It is a single-step, continuous manufacturing, and scalable method that has proved successful in improving the solubility of poorly soluble drugs. This review highlights the numerous pharmaceutical applications of HME, such as formulations of sterile implants, taste masking of unpleasant drugs, cocrystallization, salt formation, sustained and controlled release formulations, etc. It also describes various hydrophilic and hydrophobic carriers utilized in HME. This review also briefly discusses the recent advances in HME and gives an update on the currently available marketed products. The opportunities and challenges in future development of pharmaceutical products by HME technique are also discussed.

Original languageEnglish
Pages (from-to)357-373
Number of pages17
JournalPDA Journal of Pharmaceutical Science and Technology
Volume75
Issue number4
DOIs
Publication statusPublished - 01-07-2021

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

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