HPTLC method for the estimation of fexofenadine HCL in tablet dosage form

P. Solairaj, A. R. Bhat, Suvarna G. Kini, R. Govindarajan, R. Venkatraman

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The paper describes HPTLC method for the estimation of fexofenadine HCl from tablet dosage form that employs a precoated silica gel G60 F254 on aliminium sheet and a mobile phase comprising of dichloromethane; methanol (65;35%v/v) and subsequently scanned and quantified at 260 nm, the linear detector response was observed between 0.2 μg to 1.0 μg. The method so developed was validated to determine its accuracy and precision. The limit of detection and limit of quantitation was found to be 0.08ng/μl & 0.2 g/μl. The recovery was carried out by standard addition method and was found to be 100.82%.

Original languageEnglish
Pages (from-to)424-427
Number of pages4
JournalIndian Drugs
Volume42
Issue number7
Publication statusPublished - 01-07-2005

Fingerprint

fexofenadine
Dosage Forms
Tablets
Methylene Chloride
Silica Gel
Methanol
Limit of Detection

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery

Cite this

Solairaj, P., Bhat, A. R., Kini, S. G., Govindarajan, R., & Venkatraman, R. (2005). HPTLC method for the estimation of fexofenadine HCL in tablet dosage form. Indian Drugs, 42(7), 424-427.
Solairaj, P. ; Bhat, A. R. ; Kini, Suvarna G. ; Govindarajan, R. ; Venkatraman, R. / HPTLC method for the estimation of fexofenadine HCL in tablet dosage form. In: Indian Drugs. 2005 ; Vol. 42, No. 7. pp. 424-427.
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Solairaj, P, Bhat, AR, Kini, SG, Govindarajan, R & Venkatraman, R 2005, 'HPTLC method for the estimation of fexofenadine HCL in tablet dosage form', Indian Drugs, vol. 42, no. 7, pp. 424-427.

HPTLC method for the estimation of fexofenadine HCL in tablet dosage form. / Solairaj, P.; Bhat, A. R.; Kini, Suvarna G.; Govindarajan, R.; Venkatraman, R.

In: Indian Drugs, Vol. 42, No. 7, 01.07.2005, p. 424-427.

Research output: Contribution to journalArticle

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AU - Bhat, A. R.

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AU - Venkatraman, R.

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AB - The paper describes HPTLC method for the estimation of fexofenadine HCl from tablet dosage form that employs a precoated silica gel G60 F254 on aliminium sheet and a mobile phase comprising of dichloromethane; methanol (65;35%v/v) and subsequently scanned and quantified at 260 nm, the linear detector response was observed between 0.2 μg to 1.0 μg. The method so developed was validated to determine its accuracy and precision. The limit of detection and limit of quantitation was found to be 0.08ng/μl & 0.2 g/μl. The recovery was carried out by standard addition method and was found to be 100.82%.

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Solairaj P, Bhat AR, Kini SG, Govindarajan R, Venkatraman R. HPTLC method for the estimation of fexofenadine HCL in tablet dosage form. Indian Drugs. 2005 Jul 1;42(7):424-427.