Human coronaviruses in severe acute respiratory infection (SARI) cases in southwest India

Prabhu G. Suresha, Chameettachal Akhil, Aithal Anjali, Dsouza R. Giselle, Bhaskar Revti, Govindakarnavar Arunkumar

Research output: Contribution to journalArticle

Abstract

Acute viral respiratory infections (AVRI) are a leading cause of morbidity and mortality among all age groups globally. Except for Influenza virus and Respiratory Syncytial virus, mostly viral aetiology of AVRI remains undiagnosed. Lately, human coronaviruses (HCoVs) have emerged as an important aetiology of AVRI. A laboratory based retrospective cross sectional study was conducted in which respiratory samples (throat swabs) of patients (n=864), with Influenza negative SARI, of all age groups between Jan 2011-Dec 2012 were tested for HCoVs including MERS-CoV using Conventional and real time PCR assays. The prevalence of HCoV among SARI cases was 1.04% (9/864) [95% CI: 0.36-1.72]. Of these four (44.44%) were identified as HCoV OC43, three (33.33%) as HCoV NL63 and two (22.22%) as HCoV 229E. No HCoV HKU1 was detected. The samples were also negative for SARS-CoV and MERS-CoV. The results of this study documents low prevalence of human coronaviruses in SARI cases in south western India and the absence of highly pathogenic human coronaviruses. As the study included only SARI cases the prevalence reported could be an under estimate when it is extrapolated to community.

Original languageEnglish
Pages (from-to)163-165
Number of pages3
JournalJournal of Medical Virology
Volume88
Issue number1
DOIs
Publication statusPublished - 01-01-2016

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Coronavirus
Respiratory Tract Infections
India
Virus Diseases
Human Coronavirus NL63
Human Coronavirus OC43
Human Coronavirus 229E
Age Groups
SARS Virus
Respiratory Syncytial Viruses
Pharynx
Orthomyxoviridae
Human Influenza
Real-Time Polymerase Chain Reaction
Cross-Sectional Studies
Morbidity
Mortality

All Science Journal Classification (ASJC) codes

  • Infectious Diseases
  • Virology

Cite this

Suresha, Prabhu G. ; Akhil, Chameettachal ; Anjali, Aithal ; Giselle, Dsouza R. ; Revti, Bhaskar ; Arunkumar, Govindakarnavar. / Human coronaviruses in severe acute respiratory infection (SARI) cases in southwest India. In: Journal of Medical Virology. 2016 ; Vol. 88, No. 1. pp. 163-165.
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Human coronaviruses in severe acute respiratory infection (SARI) cases in southwest India. / Suresha, Prabhu G.; Akhil, Chameettachal; Anjali, Aithal; Giselle, Dsouza R.; Revti, Bhaskar; Arunkumar, Govindakarnavar.

In: Journal of Medical Virology, Vol. 88, No. 1, 01.01.2016, p. 163-165.

Research output: Contribution to journalArticle

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