Hydrogels for cancer drug delivery

Swathi Naik, T. Vamshi Krishna, Abhinaya Nayak, Mahendra Joshi, K. Girish Pai

Research output: Contribution to journalReview articlepeer-review

Abstract

Developing the assurance and potency proportion of actual chemotherapeutic medicament is an ongoing task that needs to be worked upon hand in hand with development of new chemotherapeutics agents that require a great deal of time and cost. Hydrogels have emerged as promising drug delivery systems which can efficiently provide both contiguous and sensual control over the discharge of numerous therapeutics. They have also found use in contact lens manufacture, cosmetics, hygienic products, wound healing. In addition to facilitating building up organoids and organ on a chip of hydrogels have thus become an important issue as drug delivery systems for chemotherapeutics. This review emphasis on the mechanisms of hydrogels, mechanism of hydrogel formation, their types and applications of various hydrogels as a delivery system for chemotherapeutic agent. Studies had made tremendous advances in reconstruction of the tumor form, tumor treatment and related therapies due to the special properties of hydrogels. Notably, it is possible to adjust hydrogel-based devices to react to internal stimuli specific to cancer. Such well-known medicament storage is adopted as intelligent transports for various cargoes, namely chemotherapeutics, genes, and radioisotopes, both bare and nanoparticle-encapsulated. Hydrogels can provide spatial and temporal influence over the discharge of several biomedical products, along with medicines for small molecules, macromolecular drugs and cells.

Original languageEnglish
Pages (from-to)4023-4027
Number of pages5
JournalResearch Journal of Pharmacy and Technology
Volume13
Issue number8
DOIs
Publication statusPublished - 12-08-2020

All Science Journal Classification (ASJC) codes

  • Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
  • Pharmacology (medical)

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