Abstract

Erythroderma is characterized by diffuse erythema and scaling of the skin involving more than 90% of the total body skin surface area. Drug-induced erythroderma has rarely been reported with hydroxychloroquine. We report a case of a 50-year-old female patient, with systemic lupus erythematosus, who developed itchy lesions all over the body 1 month after starting treatment with hydroxychloroquine. Drug-induced erythroderma was suspected. Hydroxychloroquine was withdrawn and the patient was treated with emollients, mid-potency corticosteroids, and oral antihistamines. A biopsy was done which confirmed the diagnosis of erythroderma. She recovered with treatment and was discharged. A careful history and clinical examination to search for potential causative factors will help prevent disabling sequelae in erythroderma.

Original languageEnglish
Pages (from-to)132-134
Number of pages3
JournalIndian Journal of Pharmacology
Volume49
Issue number1
DOIs
Publication statusPublished - 01-01-2017

Fingerprint

Hydroxychloroquine
Exfoliative Dermatitis
Emollients
Skin
Body Surface Area
Histamine Antagonists
Erythema
Pharmaceutical Preparations
Systemic Lupus Erythematosus
Adrenal Cortex Hormones
History
Biopsy
Therapeutics

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)

Cite this

Pai, Sunil B. ; Sudershan, Bhuvaneshwari ; Kuruvilla, Maria ; Kamath, Ashwin ; Suresh, Pooja K. / Hydroxychloroquine-induced erythroderma. In: Indian Journal of Pharmacology. 2017 ; Vol. 49, No. 1. pp. 132-134.
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abstract = "Erythroderma is characterized by diffuse erythema and scaling of the skin involving more than 90{\%} of the total body skin surface area. Drug-induced erythroderma has rarely been reported with hydroxychloroquine. We report a case of a 50-year-old female patient, with systemic lupus erythematosus, who developed itchy lesions all over the body 1 month after starting treatment with hydroxychloroquine. Drug-induced erythroderma was suspected. Hydroxychloroquine was withdrawn and the patient was treated with emollients, mid-potency corticosteroids, and oral antihistamines. A biopsy was done which confirmed the diagnosis of erythroderma. She recovered with treatment and was discharged. A careful history and clinical examination to search for potential causative factors will help prevent disabling sequelae in erythroderma.",
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Hydroxychloroquine-induced erythroderma. / Pai, Sunil B.; Sudershan, Bhuvaneshwari; Kuruvilla, Maria; Kamath, Ashwin; Suresh, Pooja K.

In: Indian Journal of Pharmacology, Vol. 49, No. 1, 01.01.2017, p. 132-134.

Research output: Contribution to journalArticle

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T1 - Hydroxychloroquine-induced erythroderma

AU - Pai, Sunil B.

AU - Sudershan, Bhuvaneshwari

AU - Kuruvilla, Maria

AU - Kamath, Ashwin

AU - Suresh, Pooja K.

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N2 - Erythroderma is characterized by diffuse erythema and scaling of the skin involving more than 90% of the total body skin surface area. Drug-induced erythroderma has rarely been reported with hydroxychloroquine. We report a case of a 50-year-old female patient, with systemic lupus erythematosus, who developed itchy lesions all over the body 1 month after starting treatment with hydroxychloroquine. Drug-induced erythroderma was suspected. Hydroxychloroquine was withdrawn and the patient was treated with emollients, mid-potency corticosteroids, and oral antihistamines. A biopsy was done which confirmed the diagnosis of erythroderma. She recovered with treatment and was discharged. A careful history and clinical examination to search for potential causative factors will help prevent disabling sequelae in erythroderma.

AB - Erythroderma is characterized by diffuse erythema and scaling of the skin involving more than 90% of the total body skin surface area. Drug-induced erythroderma has rarely been reported with hydroxychloroquine. We report a case of a 50-year-old female patient, with systemic lupus erythematosus, who developed itchy lesions all over the body 1 month after starting treatment with hydroxychloroquine. Drug-induced erythroderma was suspected. Hydroxychloroquine was withdrawn and the patient was treated with emollients, mid-potency corticosteroids, and oral antihistamines. A biopsy was done which confirmed the diagnosis of erythroderma. She recovered with treatment and was discharged. A careful history and clinical examination to search for potential causative factors will help prevent disabling sequelae in erythroderma.

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