Hyperpyrexia and prolonged postoperative disorientation following methylene blue infusion during parathyroidectomy

S. Mathew, L. Linhartova, Govindan Raghuraman

Research output: Contribution to journalReview article

33 Citations (Scopus)

Abstract

A 65-year-old man underwent parathyroidectomy for hyperparathyroidism secondary to renal failure. Intra-operatively he received methylene blue infusion (7.5 mg.kg-1, a total of 650 mg in 500 ml 0.9% sodium chloride) for visualisation of parathyroid glands. At the end of surgery, following extubation he developed agitation, intense shivering and hyperpyrexia, and his level of consciousness decreased to a Glasgow Coma score of 7. The differential diagnoses included methylene blue toxicity or malignant hyperpyrexia. His lungs were ventilated, and intravenous dantrolene was administered to control hyperpyrexia. Haemodialysis was started to remove the methylene blue dye. We review the literature on the pharmacological actions of methylene blue, and discuss the differential diagnosis and management of this patient.

Original languageEnglish
Pages (from-to)580-583
Number of pages4
JournalAnaesthesia
Volume61
Issue number6
DOIs
Publication statusPublished - 06-2006
Externally publishedYes

Fingerprint

Confusion
Parathyroidectomy
Methylene Blue
Differential Diagnosis
Dantrolene
Shivering
Malignant Hyperthermia
Secondary Hyperparathyroidism
Parathyroid Glands
Coma
Consciousness
Sodium Chloride
Renal Insufficiency
Renal Dialysis
Coloring Agents
Pharmacology
Lung

All Science Journal Classification (ASJC) codes

  • Anesthesiology and Pain Medicine

Cite this

Mathew, S. ; Linhartova, L. ; Raghuraman, Govindan. / Hyperpyrexia and prolonged postoperative disorientation following methylene blue infusion during parathyroidectomy. In: Anaesthesia. 2006 ; Vol. 61, No. 6. pp. 580-583.
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Hyperpyrexia and prolonged postoperative disorientation following methylene blue infusion during parathyroidectomy. / Mathew, S.; Linhartova, L.; Raghuraman, Govindan.

In: Anaesthesia, Vol. 61, No. 6, 06.2006, p. 580-583.

Research output: Contribution to journalReview article

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