Hypokalaemic periodic paralysis– A prospective study of the underlying etiologies

Surya Narayana Jandhyala, Jagadesh Madireddi, Jayaprakash Belle, N. R. Rau, Ranjan Shetty

Research output: Contribution to journalArticle

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Abstract

Background: Hypokalaemic periodic paralysis (HPP) is a rare muscular disorder characterised by episodic weakness associated with hypokalaemia. The disease can either be inherited or acquired and misdiagnosis of the disease is quite common. Most of the data available on the disease is from the western world. Studies reporting aetiological, clinical and metabolic profiles of Indian population are sparse. Hence we tried to provide insights of the disease among the Indian population. Aim: To study the aetiological, clinical and metabolic profile of patients diagnosed with Hypokalaemic Periodic Paralysis (HPP). Materials and Methods: This is an observational and analytical study on HPP diagnosed patients, during September 2011 to September 2014 in Kasturba Hospital, Manipal. A total of 23 patients were studied. Detailed history, clinical evaluation and metabolic workup for secondary causes of HPP were analysed. Results: Of the 23 patients, 57% had primary HPP while 43% had secondary HPP. The group of patients with primary HPP comprised of 92% males and 8% females with mean age of 28 years and the mean duration of symptoms of 18 hours. The group with secondary HPP comprised of 70% males and 30% females with mean age of 38.7 years and the mean duration of symptoms of 60 hours. The secondary causes of HPP were thyrotoxicosis (50%), infective diarrhea (20%), Crohn’s disease (10%), renal tubular acidosis (RTA) Type I (10%) and Conn’s syndrome (10%). Conclusion: In our study primary HPP was found to be more common than secondary HPP. Males were predominantly affected in both groups. HPP should be ruled out before starting therapy for Guillain-Barré Syndrome (GBS).

Original languageEnglish
Pages (from-to)OC17-OC19
JournalJournal of Clinical and Diagnostic Research
Volume9
Issue number9
DOIs
Publication statusPublished - 01-09-2015

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Hypokalemic Periodic Paralysis
Prospective Studies
Metabolome
Renal Tubular Acidosis
Western World
Hyperaldosteronism
Thyrotoxicosis
Hypokalemia
Diagnostic Errors
Crohn Disease
Population

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry

Cite this

Jandhyala, Surya Narayana ; Madireddi, Jagadesh ; Belle, Jayaprakash ; Rau, N. R. ; Shetty, Ranjan. / Hypokalaemic periodic paralysis– A prospective study of the underlying etiologies. In: Journal of Clinical and Diagnostic Research. 2015 ; Vol. 9, No. 9. pp. OC17-OC19.
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abstract = "Background: Hypokalaemic periodic paralysis (HPP) is a rare muscular disorder characterised by episodic weakness associated with hypokalaemia. The disease can either be inherited or acquired and misdiagnosis of the disease is quite common. Most of the data available on the disease is from the western world. Studies reporting aetiological, clinical and metabolic profiles of Indian population are sparse. Hence we tried to provide insights of the disease among the Indian population. Aim: To study the aetiological, clinical and metabolic profile of patients diagnosed with Hypokalaemic Periodic Paralysis (HPP). Materials and Methods: This is an observational and analytical study on HPP diagnosed patients, during September 2011 to September 2014 in Kasturba Hospital, Manipal. A total of 23 patients were studied. Detailed history, clinical evaluation and metabolic workup for secondary causes of HPP were analysed. Results: Of the 23 patients, 57{\%} had primary HPP while 43{\%} had secondary HPP. The group of patients with primary HPP comprised of 92{\%} males and 8{\%} females with mean age of 28 years and the mean duration of symptoms of 18 hours. The group with secondary HPP comprised of 70{\%} males and 30{\%} females with mean age of 38.7 years and the mean duration of symptoms of 60 hours. The secondary causes of HPP were thyrotoxicosis (50{\%}), infective diarrhea (20{\%}), Crohn’s disease (10{\%}), renal tubular acidosis (RTA) Type I (10{\%}) and Conn’s syndrome (10{\%}). Conclusion: In our study primary HPP was found to be more common than secondary HPP. Males were predominantly affected in both groups. HPP should be ruled out before starting therapy for Guillain-Barr{\'e} Syndrome (GBS).",
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Hypokalaemic periodic paralysis– A prospective study of the underlying etiologies. / Jandhyala, Surya Narayana; Madireddi, Jagadesh; Belle, Jayaprakash; Rau, N. R.; Shetty, Ranjan.

In: Journal of Clinical and Diagnostic Research, Vol. 9, No. 9, 01.09.2015, p. OC17-OC19.

Research output: Contribution to journalArticle

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AU - Shetty, Ranjan

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N2 - Background: Hypokalaemic periodic paralysis (HPP) is a rare muscular disorder characterised by episodic weakness associated with hypokalaemia. The disease can either be inherited or acquired and misdiagnosis of the disease is quite common. Most of the data available on the disease is from the western world. Studies reporting aetiological, clinical and metabolic profiles of Indian population are sparse. Hence we tried to provide insights of the disease among the Indian population. Aim: To study the aetiological, clinical and metabolic profile of patients diagnosed with Hypokalaemic Periodic Paralysis (HPP). Materials and Methods: This is an observational and analytical study on HPP diagnosed patients, during September 2011 to September 2014 in Kasturba Hospital, Manipal. A total of 23 patients were studied. Detailed history, clinical evaluation and metabolic workup for secondary causes of HPP were analysed. Results: Of the 23 patients, 57% had primary HPP while 43% had secondary HPP. The group of patients with primary HPP comprised of 92% males and 8% females with mean age of 28 years and the mean duration of symptoms of 18 hours. The group with secondary HPP comprised of 70% males and 30% females with mean age of 38.7 years and the mean duration of symptoms of 60 hours. The secondary causes of HPP were thyrotoxicosis (50%), infective diarrhea (20%), Crohn’s disease (10%), renal tubular acidosis (RTA) Type I (10%) and Conn’s syndrome (10%). Conclusion: In our study primary HPP was found to be more common than secondary HPP. Males were predominantly affected in both groups. HPP should be ruled out before starting therapy for Guillain-Barré Syndrome (GBS).

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