@article{838830f10ede414aab5ce853a6856c11,
title = "Identification and evaluation of antioxidant, analgesic/anti-inflammatory activity of the most active ninhydrin-phenol adducts synthesized",
abstract = "Treatment of phenols with ninhydrin in acidic medium afforded 2-hydroxy-2-(ortho-hydroxy-phenyl/naphthyl)-1,3-dioxoindanes, which being unstable were isolated in their hemiketal forms. These synthesized compounds were subjected to TLC screening for radical scavenging and in vitro lipoxgenase and cycloxygenase enzyme inhibition assays. The best compound was identified and studied in detail for steady-state and time-resolved free radical kinetics, viz., DPPH, ABTS{radical dot}-, {radical dot}OH and rate constants for these reactions were evaluated. The best compound was also subjected to in vivo anti-inflammatory and analgesic activities in which the compound showed good promise for further structural optimization. {\textcopyright} 2006 Elsevier Ltd. All rights reserved.",
author = "K.R. Prabhakar and V.P. Veerapur and P. Bansal and K.P. Vipan and K.M. Reddy and A. Barik and B.K.D. Reddy and P. Reddanna and K.I. Priyadarsini and M.K. Unnikrishnan",
note = "Cited By :42 Export Date: 10 November 2017 CODEN: BMECE Correspondence Address: Unnikrishnan, M.K.; Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal, 576 104, India; email: cheruvaloor@yahoo.com Chemicals/CAS: lipoxygenase, 9027-17-2, 9029-60-1; ninhydrin, 17596-88-2, 2462-59-1, 485-47-2, 938-24-9; phenol, 108-95-2, 3229-70-7; prostaglandin synthase, 39391-18-9, 59763-19-8, 9055-65-6; Analgesics; Anti-Inflammatory Agents; Antioxidants; Cyclooxygenase Inhibitors; Free Radicals; Lipoxygenase Inhibitors; Ninhydrin, 485-47-2; Phenol, 108-95-2 References: Ruhemann, S., (1910) Trans. Chem. Soc., 97, p. 1438; Kundu, S.K., Pramanik, A., Patra, A., (2002) Syn. lett., 5, p. 823; Klumpp, D.A., Fredrick, S., Lau, S., Jin, K.K., Bau, R., Surya Prakash, G.K., Olah, G.A., (1999) J. Org. Chem., 64, p. 5152; Kundu, S.K., Patra, A., Pramanik, A., (2004) Indian J. Chem., 43 B, p. 604; Filimonov, D.A., Poroikov, V.V., (1996) Bioactive Compound Design: Possibilities for Industrial Use, pp. 47-56. , BIOS Scientific Publishers, Oxford; Lagunin, A., Stepanchikova, A., Filimonov, D., Poroikov, V., (2000) Bioinformatics, 16, p. 747; Brooks, C.D.W., Summers, J.B., (1996) J. Med. Chem., 39, p. 2629; Lewis, R.A., Austen, K.F., (1981) Nature, 293, p. 103; Shaw, A., Krell, R.D., (1991) J. Med. Chem., 34, p. 1235; McMillan, R.M., Walker, E.R.H., (1992) Trends Pharm. Sci., 13, p. 323; Kontogiorgis, C.A., Hadjipavlou-Litina, D.J., (2002) Curr. Med. Chem., 9, p. 89; Cummings, B.S., McHowat, J., Schnellmann, R.G., (2000) J. Pharmacol. Exp. Ther., 294, p. 793; Shen, T.Y., (1980) Burger's Medicinal Chemistry, pp. 1217-1219. , Wolf M.E. (Ed), John Wiley, New York; Winter, C.A., (1965) Non-steroidal Anti-inflammatory Drugs, p. 190. , Garattini S., and Dukes M.N.G. (Eds), Excepta Medica, Amsterdam; Kuroda, T., Suzuki, F., Tamura, T., Ohmori, K., Hosoe, H., (1992) J. Med. Chem., 53, p. 1130; Reddanna, P., Whelan, J., Maddipati, K.R., Reddy, C.C., (1990) Methods Enzymol., 187, p. 268; Shimizu, T., Radmark, O., Samuelsson, B., (1984) Proc. Natl. Acad. Sci. U.S.A, 81, p. 689; Madhava Reddy, C., Bhat, V.B., Kiranmai, G., Narsa Reddy, M., Reddanna, P., Madyastha, K.M., (2000) Biochem. Biophys. Res. Commun., 277, p. 599; Copeland, R.A., Williams, J.M., Giannaras, J., Nurnberg, S., Covington, M., Pinto, D., Pick, S., Trzaskos, J.M., (1994) Proc. Natl. Acad. Sci. U.S.A., 91, p. 11202; Narla, R.S., Rao, M.N.A., (1995) J. Pharm. Pharmacol., 47, p. 623; Mishra, B., Priyadarsini, K.I., Sudheer Kumar, M., Unnikrishnan, M.K., (2003) Bioorg. Med. Chem., 11, p. 2677; Kunchandy, E., Rao, M.N.A., (1989) Int. J. Pharmaceut., 57, p. 173; Sudheer Kumar, M., Jagadish, P.C., Sridhar, R.B., Kiran, B.S., Unnikrishnan, M.K., (2003) Nahrung/Food, 47, p. 126; Kulkarni, S.K., (1984) Hand Book of Experimental Pharmacology. 3rd ed., pp. 168-171. , Vallabh Prakashan, New Delhi, India; Li, W.D., Lee, E.B., Kang, S.S., Hym, J.E., Whang, W.K., (2002) Chem. Pharm. Bull., 50, p. 900; Vogel, H.G., Vogel, W.H., (1997) Drug Discovery and Evaluation: Pharmacological Assays, p. 404. , Vogel H.G., and Vogel W.H. (Eds), Springer-Verlag, Berlin Heidelberg, Germany; Whittle, B.A., (1949) Br. J. Pharmacol., 22, p. 246",
year = "2006",
doi = "10.1016/j.bmc.2006.06.068",
language = "English",
volume = "14",
pages = "7113--7120",
journal = "Bioorganic and Medicinal Chemistry",
issn = "0968-0896",
publisher = "Elsevier Ireland Ltd",
number = "21",
}