Identification of indicators of arsenic induced hepatic damage in human

B. Dalal, K. Nayak, P. K. Gangopadhyay, A. K. Mukherjee

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Arsenic (As) exposure through contaminated drinking water is one of the environmental health hazards leading to toxicity as manifested by symptoms and signs. Little information is available on the hepatotoxic behaviour of arsenic (As) in exposed human. The aim of the present study is to assess bio indicators of hepatocellular injury, cholestasic injury, liver biosynthetic capacity, diabetogenic probability of arsenic in relation to clinical manifestation of exposed subjects and compare it with control. One hundred exposed individuals (121.95±11.30 μg/L As) and 50 control subjects (15.17±2. 07 μg/L As) of comparable age were studied. Serum aspartate transaminase (AST), alanine transaminase (ALT) and alkaline phosphatase (ALKP) increased significantly (p<.001) in tested exposed individuals with respect to control. Elevated level of serum globulin was observed in exposed subjects in comparison to control. Rising trend of blood glucose was exhibited in tested population although it was within normal range. Level of serum urea in females were elevated upon exposure but was found within normal limit. Palpability of liver was shown to increase in exposed population drinking arsenic contaminated water. Exposure-induced rise in pigmentation and keratosis was also noted. Clinically detected arsenicosis cases showed higher values of serum AST, ALT, ALKP, and Urea. Our study reveals that arsenic exposure generates stress on the liver indicated by elevation of bioindicators including hepatic enzymes.

Original languageEnglish
JournalInternet Journal of Toxicology
Volume7
Issue number1
Publication statusPublished - 29-04-2010

All Science Journal Classification (ASJC) codes

  • Toxicology

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