Abstract
Objectives: To highlight the varied clinical manifestations and management of idiopathic hypereosinophilic syndrome, a rare disorder in children. Methods: Retrospective review of case records of 3 patients who were diagnosed to have idiopathic hypereosinophilic syndrome (IHES) in a tertiary referral centre between 1997 and 2010 was performed. These 3 children presented with different symptoms and the first case had cardiac involvement. All had very high absolute eosinophil count (cells/mm3) 43,206, 9,082, 2,925, respectively. Diagnosis was confirmed by bone marrow biopsy in all three cases and supported by liver biopsy in the first two cases and inguinal lymphnode biopsy in the last case. All 3 children responded to treatment with steroids, with only second patient requiring hydroxyurea to control disease. Results: Case 1 and 2 are on follow up for 13 y and 10 y respectively and both are asymptomatic. Case 3 expired due to sepsis 1 mo after diagnosis. Conclusions: Treatment with steroids with or without hydroxyurea gave good response in all 3 cases. Hence, they still remain the gold standard for the treatment of IHES in children.
| Original language | English |
|---|---|
| Pages (from-to) | 124-127 |
| Number of pages | 4 |
| Journal | Indian Journal of Pediatrics |
| Volume | 80 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 01-02-2013 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Pediatrics, Perinatology, and Child Health
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Idiopathic hypereosinophilic syndrome in children : 3 cases with review of literature. / Kanthila, Jayashree; Bhaskaranand, Nalini.
In: Indian Journal of Pediatrics, Vol. 80, No. 2, 01.02.2013, p. 124-127.Research output: Contribution to journal › Review article
TY - JOUR
T1 - Idiopathic hypereosinophilic syndrome in children
T2 - 3 cases with review of literature
AU - Kanthila, Jayashree
AU - Bhaskaranand, Nalini
PY - 2013/2/1
Y1 - 2013/2/1
N2 - Objectives: To highlight the varied clinical manifestations and management of idiopathic hypereosinophilic syndrome, a rare disorder in children. Methods: Retrospective review of case records of 3 patients who were diagnosed to have idiopathic hypereosinophilic syndrome (IHES) in a tertiary referral centre between 1997 and 2010 was performed. These 3 children presented with different symptoms and the first case had cardiac involvement. All had very high absolute eosinophil count (cells/mm3) 43,206, 9,082, 2,925, respectively. Diagnosis was confirmed by bone marrow biopsy in all three cases and supported by liver biopsy in the first two cases and inguinal lymphnode biopsy in the last case. All 3 children responded to treatment with steroids, with only second patient requiring hydroxyurea to control disease. Results: Case 1 and 2 are on follow up for 13 y and 10 y respectively and both are asymptomatic. Case 3 expired due to sepsis 1 mo after diagnosis. Conclusions: Treatment with steroids with or without hydroxyurea gave good response in all 3 cases. Hence, they still remain the gold standard for the treatment of IHES in children.
AB - Objectives: To highlight the varied clinical manifestations and management of idiopathic hypereosinophilic syndrome, a rare disorder in children. Methods: Retrospective review of case records of 3 patients who were diagnosed to have idiopathic hypereosinophilic syndrome (IHES) in a tertiary referral centre between 1997 and 2010 was performed. These 3 children presented with different symptoms and the first case had cardiac involvement. All had very high absolute eosinophil count (cells/mm3) 43,206, 9,082, 2,925, respectively. Diagnosis was confirmed by bone marrow biopsy in all three cases and supported by liver biopsy in the first two cases and inguinal lymphnode biopsy in the last case. All 3 children responded to treatment with steroids, with only second patient requiring hydroxyurea to control disease. Results: Case 1 and 2 are on follow up for 13 y and 10 y respectively and both are asymptomatic. Case 3 expired due to sepsis 1 mo after diagnosis. Conclusions: Treatment with steroids with or without hydroxyurea gave good response in all 3 cases. Hence, they still remain the gold standard for the treatment of IHES in children.
UR - http://www.scopus.com/inward/record.url?scp=84877046794&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84877046794&partnerID=8YFLogxK
U2 - 10.1007/s12098-012-0821-x
DO - 10.1007/s12098-012-0821-x
M3 - Review article
C2 - 22740191
AN - SCOPUS:84877046794
VL - 80
SP - 124
EP - 127
JO - Indian Journal of Practical Pediatrics
JF - Indian Journal of Practical Pediatrics
SN - 0972-9607
IS - 2
ER -