Idiopathic pulmonary fibrosis and myasthenia gravis

An unusual association

Bharti Chogtu, Daliparty Vasudev Malik, Rahul Magazine

Research output: Contribution to journalArticle

Abstract

Idiopathic Pulmonary Fibrosis (IPF) is a chronic fibrosing lung condition with high morbidity and mortality, accounting for about 25% of the cases of interstitial lung diseases. It usually has a progressive course resulting in death due to respiratory failure. Myasthenia Gravis (MG) is an autoimmune neuromuscular disease, caused by antibody mediated activity against acetylcholine receptor at the neuromuscular junction. It is characterized by fluctuating muscle weakness and fatigue. Extensive literature search did not reveal any case report of an association between these two conditions. Here we present a case of a patient with IPF who also developed MG. The diagnosis of IPF was based on High Resolution Computed Tomography (HRCT) of the lung and that of MG was based on clinical criteria and electrophysiological testing. The case was successfully managed.

Original languageEnglish
Pages (from-to)OD06-OD07
JournalJournal of Clinical and Diagnostic Research
Volume10
Issue number4
DOIs
Publication statusPublished - 01-04-2016

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Idiopathic Pulmonary Fibrosis
Pulmonary diseases
Myasthenia Gravis
Cholinergic Receptors
Tomography
Muscle
Fatigue of materials
Antibodies
Testing
Lung
Neuromuscular Diseases
Muscle Fatigue
Neuromuscular Junction
Interstitial Lung Diseases
Muscle Weakness
Respiratory Insufficiency
Autoimmune Diseases
Morbidity
Mortality

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry

Cite this

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abstract = "Idiopathic Pulmonary Fibrosis (IPF) is a chronic fibrosing lung condition with high morbidity and mortality, accounting for about 25{\%} of the cases of interstitial lung diseases. It usually has a progressive course resulting in death due to respiratory failure. Myasthenia Gravis (MG) is an autoimmune neuromuscular disease, caused by antibody mediated activity against acetylcholine receptor at the neuromuscular junction. It is characterized by fluctuating muscle weakness and fatigue. Extensive literature search did not reveal any case report of an association between these two conditions. Here we present a case of a patient with IPF who also developed MG. The diagnosis of IPF was based on High Resolution Computed Tomography (HRCT) of the lung and that of MG was based on clinical criteria and electrophysiological testing. The case was successfully managed.",
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Idiopathic pulmonary fibrosis and myasthenia gravis : An unusual association. / Chogtu, Bharti; Malik, Daliparty Vasudev; Magazine, Rahul.

In: Journal of Clinical and Diagnostic Research, Vol. 10, No. 4, 01.04.2016, p. OD06-OD07.

Research output: Contribution to journalArticle

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